Antigiardial, Amoebicidal and Cytotoxic activity of the plant Prosopis juliflora leave extracts
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Date
2014
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جامعة الشيخ عبدالله البدري
Abstract
he present study was carried out to evaluate antigiardial, amoebicidal
activity and explore the cytotoxicity of Prosopis juliflora (Leaves) Variety
supreme court Leaves petroleum ether and methanolic extracts in vitro.
Tested were performed using four concentrations: (1000 ppm, 500 ppm, 250
ppm and 125 ppm). The highest activity against Giardia lamblia, with respect
to time, was obtained from petroleum ether extract which exhibited 78.91%
mortality within 72 h with a concentration of 500 ppm followed by the
methanolic extract which exhibited 77.48% mortality within 72 h with a
concentration of 1000 ppm. On the other hand the lowest antigiardial activity
was recorded by petroleum ether extract 38.55 % mortality with 1000 ppm
concentration in 24 hours. The highest activity against Entamoba
histolytica, with respect to time, was obtained from methanolic extract
which exhibited 71.97% mortality within 72 h with a concentration of 1000
ppm. On the other hand the lowest antiamobic activity was recorded by
petroleum ether extract 31.88% mortality with 125 ppm concentration within
24 hours. The cytotoxicity of methanol and petroleum ether extract had
varying degrees of toxicity to vero cell lines with IC50 731.79 µg/ml for the
methanol extract and 11.22 µg/ml for the petroleum ether extract.