Detection of secretor gene among Sudanese patients with chronic renal failure in Shendi town: A cross sectional study
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Date
2023
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Publisher
جامعة الشيخ عبدالله البدري
Abstract
Abstract:
Background: Secretor status is valuable with some diseases in clinical and forensic medicine. Objectives: This study aimed to evaluate the status of secretors and non-secretors in chronic renal failure patients under hemodialysis in Shendi town at the kidney treatment and surgery center (Sudan). Method: Saliva samples were collected from fifty patients (58% were male) aged from 15 to 65 years and secretor status was studied by the hemagglutination inhibition method of saliva. Result: results showed that 68% of the study population were non-secretors. probable frequency of the Se and se genes was 17,6% and 82,4% while the frequency of SeSe, Sese, and sese allele genes was 3%, 29%, and 68% respectively. were calculated by utilizing Hardy-Weinberg Theorem for probabilities and possibilities. Frequencies of the non-secretor status among various ABO blood groups were 63.2% in group A, 75% in group B, and 72.7% in group O. Conclusion: We conclude that non-secretors are more prevalent in chronic renal failure. In the present study observed that non-secretors were more common as compared to secretors, non-secretors are more prone to renal failure.