Antiamoebic and Cytotoxicity of Ethanolic Fruit Extract of Kigelia africana

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جامعة الشيخ عبدالله البدري
Kigelia africana (family Bignoniaceae), is a common component of the pharmacopeia’s of multiple African groupings which inhabit the areas in which it grows. Amongst these groups there is a myriad of medicinal uses in the treatment of a wide variety of bacterial, fungal and protozoal infections, as well as in the treatment of cancers. Intestinal amoebiasis due to the infection of E. histolytica is ranked third on the list of parasitic protozoan infections leading to death behind malaria and schistosomiasis. This study was carried out to evaluate antiamoebic activites (E. histolyica) and cytotoxicity (MTT assay) of ethanol extract of K. africana (fruits). The extract of K. africana (fruits), with different concentrations (500, 250 and 125 ppm) and Metronidazole concentration (312.5 μg/ml) to be investigated in vitro against E. histolyica trophozoites, and cytotoxicity (MTT) assay with test concentrations and Triton-100 (the reference control) was studied. The ethanolic fruit extract exhibited 100% mortality within 96 h, at a concentration 500 ppm, whereas, metronidazole gave 96% inhibition at concentration 312.5 µg/ml. MTT assay verified the safety of the examined extract. The studies conducted for K. africana fruit extract was proved to have potent activities against E. histolyica trophozoites in vitro