Browsing by Author "Mosab Nouraldein Mohammed Hamad,"
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Item Evaluation of Iron Profiles and Coagulation Profiles in Ischemic Heart Diseases Patients in Elmer Nimr Hospital, Sudan(جامعة الشيخ عبدالله البدري, 2023-04-27) Mosab Nouraldein Mohammed Hamad,Abstract Back ground chemic heart disease (IHD) isa constellation of diseases that includes stableangina,unstableangina,myocardialinfarction,andsuddencardiacdeath.It belongs to the group of cardiovascular diseases and is the most common type among them. Iron is an essential trace element .it plays an important role in maintaining various cellular function and enzymatic reactions. On the other hand, excessive intake of iron is known to be a risk factor for the progression of atherosclerosis. Abnormal iron deposition in the heart causes hem chromatists and dilated cardiomyopathy, which leads to is chemic heart disease .Objectives :This study aims to investigate the role of serum iron ,serum ferritin ,total iron-binding capacity(TIBC), PT, and PTT in is chemic heart disease(IHD)and their relationship with other risk factors for IHD This is a prospective, case-control, cross-sectional analytical study conducted at Elmer Narmer University Hospital, Shendi City, to assess their on profile and coagulation profile of patients with is chemic heart disease. The study included (30) patients diagnosed with is chemic hear the diseases and the study group was compared with the mean of the control group (20). Serum iron ,ferritin ,and TIBC were estimated using a Spectro photo meter ,and PT and PTT were estimated using manual methods. Data were collected using a structured personal questionnaire and the program (SPSS) version(11.5)was used for data analysis In this study, patients with is chemic heart disease were (40%)male and (60%) female. In this study, iron averaged (41.0) ug/dl (Value 0.010), ferritin averaged (233.0) ug/dl (Value 0.000), and TIBC averaged (44.0) μg/dl. Was shown. (Value 0.000) compared to mean controls (27.0), (162.0), (56.0). A significance difference was found between their on profile and his IHD. This study showed the mean PT,PTT for cases (13.4), (40.4) (P-value 0.024), (P. value 0.009) compared with the mean for controls (12.0), (35.1). A significant difference was found between the coagulation profile and IHD Cardiovascular disease (CVD)isa type of disease that affects the heart ,blood vessels(arteries ,capillaries, veins),or both[1]. Cardiovascular diseases refers to all diseases that affect the cardiovascular system, primarily heart disease, cerebral and renal vascular disease, and peripheral arterial disease [2]. The causes of cardi vascular disease are varied ,but at her sclerosis /or hyper tension are the most common [3]. In addition, a variety of physiological and b biochemical changes alter cardiovascular function in association with aging, leading to an increased risk of subsequent cardiovascular disease, even in healthy a symptom at in individuals[4].Cardiovascular disease is leading cause of death.In2008, 30% (30%)of fall deaths worldwide were due to cardio vascular disease. Mortality from cardiovascular disease is also higher in low- and middle-income countries, as more than 80% of all cardiovascular deaths occur in these countries [5].It is also estimated that by 2030 more than 23 million people will die annually from cardio vascular disease [5,6]. The causes, diagnosis ,prevention ,control, and /or treatment of all forms of the cardiovascular disease continue to be an active area of biomedical research ,with hundreds of scientific studies published each week. I'm here. In 2013, coronary heart disease (CHD) was the leading cause of death worldwide, with (8.14)million deaths ( 16.8%) compared with (5.74)million deaths12%)in1990 [7] the risk of dying from(CAD) at a given age decreasedbetween1980and2010,especiallyindeveloped countries[8]The number of cases of (CAD) in a given age group alsodecreasedbetween1990and2010[9].In the United States in 2010, approximately (20%)of (ages 65+) had (CAD (CAD),while(7%)and(1.3%) (Ages 45–64) (CAD) of (18-45 years old) Now. (10) More Mentha women at alienage [10].The Sudan H house hold Survey(SHHS)reported a prevalence of heart disease (2.5%). Hypert tensive heart disease(HHD),rheumatic heart diseases(RHD), ischemic heart disease(IHD),and cardiomyopathy account for more than (80%) of(CVD) in Sudan [6]. Heart disease is the leading cause of morbidity and mortality yin Sudan. Hypertension (RHD), (IHD), and cardio myopathy account for the majority of four (CVD).Hyper tensions common and poorly controlled [11]. Most cardiovascular diseases can be prevented by addressing risk factors such as to because, unhealthy diet obesity ,physical inactivity, hypertension, diabetes, and elevated lipids. More than half of the heart disease deaths in 2009 were men. Coronary heart disease (CHD)is the most common heart disease causing more than (385,000) deaths each year[6]. Ischemic heartseases associated with progressive mechanical obstruction, dynamic obstruction, plaque inflammation, instability, and rupture, followed by super imposed thrombosis . Clinicians are employ in additional tools to aid clinical assessment and improve their ability to identify &quo that -risk "e; patients who are at risk for cardiovascular disease[12,13].Bio mark arrasene of the tools to better identify at-risk individuals ,diagnose medical conditions quickly and a cure lately ,and effectively diagnose and treat sick patients. Biomarkers can be measured in biological samples (as blood, urine ,or tissue tests), can be human records (blood pressure, electrocardiogram, or holder), or imaging tests (echocardiogram).Normally very small amounts of iron are present tin most body cells, plasma ,and other extracellular fluids ,under body strictly limits its iron supply so that every day (0.1%)of the body's microcontents lost. maintain. Mainly in desquamated cells [14]Iron `s high activity is a two- Edged word, and free iron ions in the body also participate in destructive chemistry ,primary catalyzing the formation of toxic free radicals .Iron play role in the process of at hero sclerosis by catalyzing the formation of free radical and also this contributes to reperfusion Damage .High serum ferric tin concentration was associated with increased risk of my dial infarction, independent of major cardiovascular risk factors. Abnormal deposition of iron in the heart cause phenom at sis and dilated cardiomyopathy and this causes or imaging tests (echocardiogram).Normally very small amounts of iron are present tin most body cells, plasma, and other extracellular fluids ,under body strictly limits its iron supply so that every day (0.1%)of the body's microcontents lost. maintain. Mainly in desquamated cells [14]Iron `s high activity is a two- Edged word, and free iron ions in the body also participate in destructive chemistry ,primary catalyzing the formation of toxic free radicals .Iron play role in the process of at hero sclerosis by catalyzing the formation of free radical and also this contributes to reperfusion Damage .High serum ferric tin concentration was associated with increased risk of my dial infarction, independent of major cardiovascular risk factors. Abnormal deposition of iron in the heart cause phenom at sis and dilated cardiomyopathy and this causes causing is chemic heart disease [1].Coagulation play roe in is chemic heart disease ,increase plasm a level so coagulation in are associated with an increased risk of my ocarina infarction The orthro in time alone is derived from measures of prothrombin in ratio{PR}and intermate on abnormalized ratio{INR] are essays evaluating the extrinsic pathway bayan dc ammonal way of coagulation. They are used to determine the clotting tendency of blood in homes of war farinose[2]. The role of blood clotting activation such as elevated circulating level of Amar cero fathom Bing enervation and fibro in peptide A in the occurrence of angina in I s chemic heart disease[3].Activated thromboplastin tin time issued to monitor the effects of the part non intrinsic pathways and detect defects in factors XII, XI, IX, VIII, and the common pathway .This study concluded that serum levels of iron ,ferret in ,TI, BC ,PT ,and PTT may be associated with is chemic heart disease.Item Influences of meteorological factors on COVID.19 pandemic: prevalence and outcomes(جامعة الشيخ عبدالله البدري, 2020) Mosab Nouraldein Mohammed Hamad,; Sufian Khalid Mohammed Nor; Abdul Jabbar; Elizaveta V Popova; Mohamed BuhejiAbstract In late of 2019 Coronavirus pandemic started from China (Wuhan Province) and then later spread to the world. The authors set forth a debate about the most important factors which influenced the feast and even the consequences of COVID-19 and then the foresight of COVID-20, which is the climate change and its related meteorological factors. Climate change found to affect directly on virus activation and indirectly on the host behavior and even immune response. Persons live in cold, arid and air polluted areas suffer from both spreads of the pandemic and serious complications of the COVID19 infection, due to low level of vitamin D, low activity of thyroid gland, with low levels of thyroid hormones (T3,T4 and TSH) and reduction in angiotensin 2 level. Aged persons living in these zones are the most victims from this pandemic. We conclude that persons living in the industrialized countries zones are affected more than those under the same meteorological circumstances in non-industrialized countries due to low air pollution.Item Massive pericardial effusion resulted from hypothyroidism: a case report((جامعة الشيخ عبدالله البدري), 2021) Sufian Khalid M. Nor,; Yousif Abdullah,; AbubakerTagelssir Taha Mohammed,; Mohamed H. Ahmed; Sarra O Bushara,; Mosab Nouraldein Mohammed Hamad,; Samaher Mozamil Mohamed Abdelrahim,; Remaz Khalid Hassan Ahmed,; Almoatasim Mohamed Aabdelmagid Elnaema,; Mohammed Adil Yassen AliAbstract Hypothyroidism is an endocrine disorder characterized by high level of thyroid stimulating hormone and normal or low level of free thyroxine 4 (FT4). Mild pericardial effusion may complicate hypothyroidism but massive pericardial effusion or cardiac tamponade is quite uncommon. A 40 year old female presented to our emergency unit complaining of worsening shortness of breath for one week, transthoracic echocardiography revealed massive pericardial effusion. Laboratory examination showed elevated thyroid stimulating hormone (TSH), and decreased thyroxine (T4) and triiodothyronine (T3) levels. The patient diagnosed as a case of primary hypothyroidism complicated by pericardial effusion and treated with L-thyroxine replacement therapy. Possibility of hypothyroidism should be put in mind when assessing cases of pericardial effusion, even if there were no overt features of the disease, especially when other commoner causes of pericardial effusion were excluded.Item Prevalence of intestinal parasitic infections among school aged children in Berber locality, River Nile State, Sudan 2017(جامعة الشيخ عبدالله البدري, 2019-03-27) Mosab Nouraldein Mohammed Hamad,; Ayman Abdelrahman Mokhtar,; , Yousif Mohammed Abkar,; Mazin alameldin; Muzameil EltoumAbstract Background: Intestinal parasitic infections are amongst the most widespread infections throughout the globe. It is estimated that 3.5 billion people are affected, and that 450 million are ill as a consequence of these infections, the majority being children. Justification: There is no previous study about the prevalence of intestinal parasitic infection among school aged children in Berber area. Objectives: To know the Prevalence of the intestinal parasitic infections between schools aged children in Berber. Method: Hundred primary school aged children were involved in the study, stool specimens were examined by direct wet preparation and formal ether centrifugation concentration method. Result: Out of 100 students examined 87.2% had infection with intestinal parasites. Conclusion: The prevalence of intestinal parasitic infection among the participants was very high.Item Seroprevalence of torch infections among complicated pregnancies in Atbara river Nile state - Sudan(جامعة الشيخ عبدالله البدري, 2021-02-12) Mohammed Ahmed Ibrahim Ahmed,; Hanaa Elzain Musaad,; Nahla Ahmed Mohammed Abdurrahman,; Wadei Mohammed Yasin,; Mosab Nouraldein Mohammed Hamad,; Nassreldeen Khalid Abdelrahman,; Emad Ibrahim OsmaAbstract Objective: The aim of this study was to find the seroprevalence of TORCH infection among volunteered pregnant women and to find out the correlation between TORCH infection and age, complicated pregnancies and education level. Methods: A descriptive cross-sectional laboratory-based study carried out between March to June 2012 at Atbara River Nile State northern Sudan. The statistical descriptive determined in means of percentages. Chi-square used for trend analysis and calculates p-values. Results: A total of (75) voluntary pregnant women, Age between 15-55 years. The most common age group was 26-35 years (37/75) 49%.Serological evidence of Toxoplasmosis were positive for (22/75) 29 %. All volunteered pregnant women were negative for other components of TORCH complex. Study showed non-significant correlation between age, education level and complicated pregnancies, P-value 0.13, 0.43 and 0.51 respectively. Conclusion: Low prevalence of Toxoplasmosis and absent of serological evidence of other TORCH complex among volunteered pregnant women in Atbara has been documented. Insignificant correlation between toxoplasmosis and age, education level as well as number of complicated pregnancies reported. This attributed, in part, to the small sample size and using screening tool as diagnostic modalities.