Browsing by Author "Mohammed Bahreldin Hussein"
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Item GC-MS Analysis, Antimicrobial and Antioxidant Activity of Sudanes Adansoina digitata L; (Malvaceae) Fixed Oil(جامعة الشيخ عبدالله البدري, 2020-08-22) Mosab Nouraldein Mohammed Hamad; Mohammed Bahreldin HusseinAbstract Medicinal plants are source of a great economic value. Plants herbs are naturally gifted at the synthesis of medicinal compounds. The extraction and characterization of bioactive compounds from medicinal plants have resulted in the discovery of new drugs with high therapeutic value. Baobab Adansonia digitata L., (Malvaceae) seeds were collected from El-Obeid, North Kordofan state Sudan, and were extracted with hexane as solvent the extracted oil was analyzed by GC-MS. Twenty four constituents were detected the major constituents are: 9-octadecanoic acid methyl ester (25.08), 9,12-Octadecadienoic acid (Z,Z)-, methyl ester (23.08), Hexadecanoic acid, methyl ester (22.78), Methyl stearate (6.86) and Methyl 2-octylcyclopropene-1-heptanoate (6.08). In the well diffusion bioassay the oil showed significant activity against Bacillus subtilis, Pseudomonas aeroginosa, Staphylococcus aureus, and the yeast Candida albicans but it was partially active against Escherichia coli. The antioxidant activity of the extracted oil was evaluated using the standard 2, 2diphenyl-1-picrylhydrazyl (DPPH) 0.5 ml. The antioxidant activity of the extracted oil was 19.00 ± 0.08. .Item Phytochemical Screening, Antimicrobial and Antioxidant Activity of Ziziphus Spina-Christi (L.) (Rhamnaceae) Leaves and Bark extracts(جامعة الشيخ عبدالله البدري, 2023-02-01) Mohammed Bahreldin Hussein; Mosab Nouraldein Mohammed HamadAbstract This study aimed to determine the preliminary phytochemical component, the antioxidant and antibacterial activity of the leaves and bark extracts of Ziziphus spina-christi (L.) (Rhamnaceae) against two clinical isolates (Staphylococcus aureus and Escherichia coli species) using the standard method of analysis. The test for the phytochemical component revealed the presence of flavonoids, alkaloids, saponins, tannins, steroids, terpenoids and glycosides. The result of antibacterial activity showed that the bark ethanolic extract exhibit a higher zone of inhibition against all the clinical isolates; Escherichia coli species showed zones of inhibition of 22mm followed by Staphylococcus aureus 15mm. The antioxidant activity of the leaves and bark extracts was evaluated using the standard 2,2 diphenyl-1- picrylhydrazyl (DPPH) 0.5 ml. The antioxidant activity of the leaves water and ethanolic extracts was 30 ± 0.05 and 91 ± 0.02 respectively and the antioxidant activity of the bark water and ethanolic extracts was 44 ± 0.03 and 70 ± 0.02 respectively.Item Synthesis, Characterization and Antimicrobial Study of 3- nitrobenzaldehyde Thiosemicarbazone and it's Metal Complexes(جامعة الشيخ عبدالله البدري, 2020-12-01) Mohammed Bahreldin Hussein; Anwar Hamed Nassri; Mosab Nouraldein Mohammed HamadAbstract: This study was carried out to synthesize and characterize 3-nitrobenzealdhyde thiosemicarbazone ligand and it's transitional metal complexes with Nickel(II), Copper(II), and Cobalt(II) and to evaluate their activity against bacteria and fungi. The synthesized compounds were characterized by FT-IR and UV methods. The results of FT-IR and UV spectra of the ligand and its metal complexes confirm the formation of azomethine group (-C=N-H) accompanied with the absence of carbonyl group (C=O) and formation of (M-N) and (M-S) bonds with all metal ions. The results assign that the ligand is neutral and bidentate species which coordinated via azomethine N and thione S with all three metal ions and the silver nitrate test indicates that the chloride ion was out of coordination sphere. The antimicrobial activity of the ligand and its metal complexes against four types of bacteria (Bacillus subtilis, Staphylococcus aureus (Gram +ve) Escherichia coli and Pseudomonas aeruginosa (Gram –ve) and one fungi (Candida ablicans) with different concentrations (75 and 100)mg/ml was carried out using disc diffusion method. The results showed that the free ligand and Copper (II) complex were inactive against all types of bacteria and fungi and the Nickel(II) and Cobalt(II) complexes exhibited different activities against four types of bacteria and fungi