Synthesis, Characterization and Antimicrobial Study of 3- nitrobenzaldehyde Thiosemicarbazone and it's Metal Complexes
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Date
2020-12-01
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Publisher
جامعة الشيخ عبدالله البدري
Abstract
Abstract:
This study was carried out to synthesize and characterize 3-nitrobenzealdhyde
thiosemicarbazone ligand and it's transitional metal complexes with Nickel(II),
Copper(II), and Cobalt(II) and to evaluate their activity against bacteria and fungi. The
synthesized compounds were characterized by FT-IR and UV methods. The results of
FT-IR and UV spectra of the ligand and its metal complexes confirm the formation of
azomethine group (-C=N-H) accompanied with the absence of carbonyl group (C=O) and
formation of (M-N) and (M-S) bonds with all metal ions. The results assign that the
ligand is neutral and bidentate species which coordinated via azomethine N and thione
S with all three metal ions and the silver nitrate test indicates that the chloride ion was
out of coordination sphere. The antimicrobial activity of the ligand and its metal
complexes against four types of bacteria (Bacillus subtilis, Staphylococcus
aureus (Gram +ve) Escherichia coli and Pseudomonas aeruginosa (Gram –ve) and one
fungi (Candida ablicans) with different concentrations (75 and 100)mg/ml was carried
out using disc diffusion method. The results showed that the free ligand and Copper (II)
complex were inactive against all types of bacteria and fungi and the Nickel(II) and
Cobalt(II) complexes exhibited different activities against four types of bacteria and
fungi