Synthesis, Characterization and Antimicrobial Study of 3- nitrobenzaldehyde Thiosemicarbazone and it's Metal Complexes

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جامعة الشيخ عبدالله البدري
Abstract: This study was carried out to synthesize and characterize 3-nitrobenzealdhyde thiosemicarbazone ligand and it's transitional metal complexes with Nickel(II), Copper(II), and Cobalt(II) and to evaluate their activity against bacteria and fungi. The synthesized compounds were characterized by FT-IR and UV methods. The results of FT-IR and UV spectra of the ligand and its metal complexes confirm the formation of azomethine group (-C=N-H) accompanied with the absence of carbonyl group (C=O) and formation of (M-N) and (M-S) bonds with all metal ions. The results assign that the ligand is neutral and bidentate species which coordinated via azomethine N and thione S with all three metal ions and the silver nitrate test indicates that the chloride ion was out of coordination sphere. The antimicrobial activity of the ligand and its metal complexes against four types of bacteria (Bacillus subtilis, Staphylococcus aureus (Gram +ve) Escherichia coli and Pseudomonas aeruginosa (Gram –ve) and one fungi (Candida ablicans) with different concentrations (75 and 100)mg/ml was carried out using disc diffusion method. The results showed that the free ligand and Copper (II) complex were inactive against all types of bacteria and fungi and the Nickel(II) and Cobalt(II) complexes exhibited different activities against four types of bacteria and fungi