Browsing by Author "Awadalla H Kashif"

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    Does Hyperuricemia in Falciparum Malaria Infected Children Explains the Etiology of Burkitt’s Lymphoma?
    (جامعة الشيخ عبدالله البدري, 2022-04-20) Mosab Nouraldein Mohammed Hamad; Sufian Khalid M. Noor; Rania Saad Abdulgader; Awadalla H Kashif
    Abstract: Falciparum malaria still represents the big obstacle to communities in Sub-Sahara African countries and more concentrated efforts against COVID-19 pandemic, may influence the lives of millions of children in that malaria endemic area. Hyperuricemia associated with plasmodium falciparum infection reflects the density of parasitemia and it may lead to kidney injury, resulting in low vitamin D production. Furthermore, hyperuricemia leads to high levels of proinflammatory cytokines counting interferon γ-induced protein, which is invested vitamin D deficiency in the development of Burkitt’s lymphoma. Experimental research is required.
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    Impact of Uric Acid in Malaria Outcomes
    (جامعة الشيخ عبدالله البدري, 2021) Mosab Nouraldein Mohammed Hamad; Yassin Bakri Salih; Sufian Khalid M. Noor; Awadalla H Kashif; Mohammed Medani Eltayeb; Bader Saud Alotaibi; Elizabeth Popova; Rania Saad Abdulgader; Abdelgadir Elamin Eltom; Shafie Abdulkadir Hassan; Tarig Mohamed Elfaki1; Mohammed Ahmed Ibrahim Ahmed
    Up to the date variations of malaria pathogenesis between human populations signify important trouble facing scholars concerned with malaria pathology. Pathogen-associated molecular patterns may be one of the main keys to the well understanding of malaria mechanism and dissimilarity of clinical outcomes of the disease between people. Uric acid is regarded as a dangerous alarming metabolite, resulting from plasmodium activity inside infected red blood cells, furthermore, levels of uric acid correlate with the development of intracellular malaria parasites. Hypoxanthine resulting from the breakdown of haemoglobin by Plasmodium species is very important in malaria pathogenesis, because plasmodia use it as a nutrient and after rupture of schizonts the remaining of it is converted to uric acid due to the action of Xanthine oxidase, and that gave a strong linkage between malaria pigment density and severity of malaria infection. Uric acid is the main cause of arthritis which is one of the common clinical features of malaria, it induces the inflammatory response and many cytokines involved, genes related to hyperuricemia involved discrepancy of clinical outcomes between malaria patients.
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    Medicinal Plants Explain the Significant Role of Uric Acid for Malaria Parasite
    (جامعة الشيخ عبدالله البدري, 2021-12-13) Mosab Nouraldein Mohammed Hamad; , Sufian Khalid M. Noor; Awadalla H Kashif; , Mohammed Medani Eltayeb; Abdelgadir Elamin Eltom; , Praveen Kumar Kandakurti; , Elizabeth Popova; Shafie Abdulkadir Hassan; , Yassin Bakri Salih; , Tarig Mohammed Elfaki; d Mohammed Ahmed Ibrahim Ahmed
    Medicinal plants, recognized and employed in conventional medicine practices since prehistoric era. Plants produce thousands of chemical substances for functions counting defence against insects, fungi, bacterial and parasitic diseases. Malaria is most widespread parasitic infection , it caused by coccidian protozoa of the genus plasmodium , four species are mostly infect human, P. falciparum, P. vivax, P. malriae and P. ovale, Majority of malaria cases resulted from P. falciparum and P. vivax. Uric acid regarded as one of the damaging molecular patterns of malaria parasite infection, and in this review we discussed the potential role of medicinal plants used as antimalarial to diminish the level of uric acid in gout patients. These may suggest that most of the complication associated with malaria, may attributed to amplified level of uric acid . Experimental studies recommended.
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    The Role of Aryl Hydrocarbon Receptor in Malaria Immunity During Adulthood, Childhood and Pregnancy: A review
    (جامعة الشيخ عبدالله البدري, 2021) Mosab Nouraldein Mohammed Hamad; Bader Saud Alotaibi; Rania Saad Abdulgader; Sufian Khalid M. Noor; Rimma Chanysheva; Awadalla H Kashif
    Abstract Malaria is most prevalent parasitic disease , it caused by coccidian parasite of the genus plasmodium , four species are usually infect human beings, P. falciparum, P. vivax, P. malriae and P. ovale, Most of malaria cases resulted from P. falciparum and P. vivax. Aryl hydrocarbon receptor (AHR) is an environmental sensor exists in many parts of human body such as lung , spleen , gut and breast . In this review we discussed the functions of it as regulator for proinflammatory and anti-inflammatory cytokines , the possible role of diet during pregnancy and breastfeeding in boosting immunity against malaria during pregnancy and childhood by triggering AHR. Also we hypothesize that probable role of it in synchronizing erythrocytic schizogongy. Experimental studies recommended to know more about the biological protective functions of AHR