The Role of Aryl Hydrocarbon Receptor in Malaria Immunity During Adulthood, Childhood and Pregnancy: A review
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Date
2021
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جامعة الشيخ عبدالله البدري
Abstract
Abstract
Malaria is most prevalent parasitic disease , it caused by coccidian parasite of the
genus plasmodium , four species are usually infect human beings, P. falciparum, P.
vivax, P. malriae and P. ovale, Most of malaria cases resulted from P. falciparum and
P. vivax. Aryl hydrocarbon receptor (AHR) is an environmental sensor exists in
many parts of human body such as lung , spleen , gut and breast . In this review we
discussed the functions of it as regulator for proinflammatory and anti-inflammatory
cytokines , the possible role of diet during pregnancy and breastfeeding in boosting
immunity against malaria during pregnancy and childhood by triggering AHR. Also
we hypothesize that probable role of it in synchronizing erythrocytic schizogongy.
Experimental studies recommended to know more about the biological protective
functions of AHR