In vitro antitrichomonas activity of lowsonia inerimtes – activity

Abstract

Trichomonas vaginalis infection is one of the major health problems in the world, and the most common transmitted infections in many regions including the developed countries such as United State (Parbara, Van Der Pol, 2005). Trichomonas vaginalis infection should not be considered as a simple vaginal infection that serves markers for others sexually transmitted diseases in recent years. Moreover, Trichomonas vaginalis infection have been associated with several adverse outcomes including adverse pregnancy, pelvic inflammatory premature delivery,, infertility, postoperative infections, low birth weight, cervical neoplasia and increased susceptibility to HIV infection (Schwebke, et al 1997). Medicinal plants are still invaluable source of safe, less toxicity, lower price, available and reliable natural resources of drugs all over the world, despite the bulk work which have been done in this concern by Sudanese researcher; it is undoubtedly that this field remains rich and not wholly exploited (Gamal, et al 1994). Thus the need of alternative drugs to reduce their burden of purchasing the synthetic drugs especially after the problem of getting resistant to many clinical patients against metronidazole (Iran, et al 2006; Pratibha et al, 2008). In addition, metronidazole sometimes causes adverse effects, e.g., myopia, neuralgia, and allergic dermatitis (Upcrof et al, 2006), and thus new anti-trichomonal drugs are probably required. Sudan is rich in medicinal flora with antiprotozoal, antimicrobial and antifungal activities like Acacia nilotica (EL-Kamali, et al 1996).