Evaluation of Iron Profiles and Coagulation Profiles in Ischemic Heart Diseases Patients in Elmer Nimr Hospital, Sudan

Simple item page
dc.contributor.authorMosab Nouraldein Mohammed Hamad,
dc.date.accessioned2023-11-21T10:00:07Z
dc.date.available2023-11-21T10:00:07Z
dc.date.issued2023-04-27
dc.description.abstractAbstract Back ground chemic heart disease (IHD) isa constellation of diseases that includes stableangina,unstableangina,myocardialinfarction,andsuddencardiacdeath.It belongs to the group of cardiovascular diseases and is the most common type among them. Iron is an essential trace element .it plays an important role in maintaining various cellular function and enzymatic reactions. On the other hand, excessive intake of iron is known to be a risk factor for the progression of atherosclerosis. Abnormal iron deposition in the heart causes hem chromatists and dilated cardiomyopathy, which leads to is chemic heart disease .Objectives :This study aims to investigate the role of serum iron ,serum ferritin ,total iron-binding capacity(TIBC), PT, and PTT in is chemic heart disease(IHD)and their relationship with other risk factors for IHD This is a prospective, case-control, cross-sectional analytical study conducted at Elmer Narmer University Hospital, Shendi City, to assess their on profile and coagulation profile of patients with is chemic heart disease. The study included (30) patients diagnosed with is chemic hear the diseases and the study group was compared with the mean of the control group (20). Serum iron ,ferritin ,and TIBC were estimated using a Spectro photo meter ,and PT and PTT were estimated using manual methods. Data were collected using a structured personal questionnaire and the program (SPSS) version(11.5)was used for data analysis In this study, patients with is chemic heart disease were (40%)male and (60%) female. In this study, iron averaged (41.0) ug/dl (Value 0.010), ferritin averaged (233.0) ug/dl (Value 0.000), and TIBC averaged (44.0) μg/dl. Was shown. (Value 0.000) compared to mean controls (27.0), (162.0), (56.0). A significance difference was found between their on profile and his IHD. This study showed the mean PT,PTT for cases (13.4), (40.4) (P-value 0.024), (P. value 0.009) compared with the mean for controls (12.0), (35.1). A significant difference was found between the coagulation profile and IHD Cardiovascular disease (CVD)isa type of disease that affects the heart ,blood vessels(arteries ,capillaries, veins),or both[1]. Cardiovascular diseases refers to all diseases that affect the cardiovascular system, primarily heart disease, cerebral and renal vascular disease, and peripheral arterial disease [2]. The causes of cardi vascular disease are varied ,but at her sclerosis /or hyper tension are the most common [3]. In addition, a variety of physiological and b biochemical changes alter cardiovascular function in association with aging, leading to an increased risk of subsequent cardiovascular disease, even in healthy a symptom at in individuals[4].Cardiovascular disease is leading cause of death.In2008, 30% (30%)of fall deaths worldwide were due to cardio vascular disease. Mortality from cardiovascular disease is also higher in low- and middle-income countries, as more than 80% of all cardiovascular deaths occur in these countries [5].It is also estimated that by 2030 more than 23 million people will die annually from cardio vascular disease [5,6]. The causes, diagnosis ,prevention ,control, and /or treatment of all forms of the cardiovascular disease continue to be an active area of biomedical research ,with hundreds of scientific studies published each week. I'm here. In 2013, coronary heart disease (CHD) was the leading cause of death worldwide, with (8.14)million deaths ( 16.8%) compared with (5.74)million deaths12%)in1990 [7] the risk of dying from(CAD) at a given age decreasedbetween1980and2010,especiallyindeveloped countries[8]The number of cases of (CAD) in a given age group alsodecreasedbetween1990and2010[9].In the United States in 2010, approximately (20%)of (ages 65+) had (CAD (CAD),while(7%)and(1.3%) (Ages 45–64) (CAD) of (18-45 years old) Now. (10) More Mentha women at alienage [10].The Sudan H house hold Survey(SHHS)reported a prevalence of heart disease (2.5%). Hypert tensive heart disease(HHD),rheumatic heart diseases(RHD), ischemic heart disease(IHD),and cardiomyopathy account for more than (80%) of(CVD) in Sudan [6]. Heart disease is the leading cause of morbidity and mortality yin Sudan. Hypertension (RHD), (IHD), and cardio myopathy account for the majority of four (CVD).Hyper tensions common and poorly controlled [11]. Most cardiovascular diseases can be prevented by addressing risk factors such as to because, unhealthy diet obesity ,physical inactivity, hypertension, diabetes, and elevated lipids. More than half of the heart disease deaths in 2009 were men. Coronary heart disease (CHD)is the most common heart disease causing more than (385,000) deaths each year[6]. Ischemic heartseases associated with progressive mechanical obstruction, dynamic obstruction, plaque inflammation, instability, and rupture, followed by super imposed thrombosis . Clinicians are employ in additional tools to aid clinical assessment and improve their ability to identify &quo that -risk &quote; patients who are at risk for cardiovascular disease[12,13].Bio mark arrasene of the tools to better identify at-risk individuals ,diagnose medical conditions quickly and a cure lately ,and effectively diagnose and treat sick patients. Biomarkers can be measured in biological samples (as blood, urine ,or tissue tests), can be human records (blood pressure, electrocardiogram, or holder), or imaging tests (echocardiogram).Normally very small amounts of iron are present tin most body cells, plasma ,and other extracellular fluids ,under body strictly limits its iron supply so that every day (0.1%)of the body's microcontents lost. maintain. Mainly in desquamated cells [14]Iron `s high activity is a two- Edged word, and free iron ions in the body also participate in destructive chemistry ,primary catalyzing the formation of toxic free radicals .Iron play role in the process of at hero sclerosis by catalyzing the formation of free radical and also this contributes to reperfusion Damage .High serum ferric tin concentration was associated with increased risk of my dial infarction, independent of major cardiovascular risk factors. Abnormal deposition of iron in the heart cause phenom at sis and dilated cardiomyopathy and this causes or imaging tests (echocardiogram).Normally very small amounts of iron are present tin most body cells, plasma, and other extracellular fluids ,under body strictly limits its iron supply so that every day (0.1%)of the body's microcontents lost. maintain. Mainly in desquamated cells [14]Iron `s high activity is a two- Edged word, and free iron ions in the body also participate in destructive chemistry ,primary catalyzing the formation of toxic free radicals .Iron play role in the process of at hero sclerosis by catalyzing the formation of free radical and also this contributes to reperfusion Damage .High serum ferric tin concentration was associated with increased risk of my dial infarction, independent of major cardiovascular risk factors. Abnormal deposition of iron in the heart cause phenom at sis and dilated cardiomyopathy and this causes causing is chemic heart disease [1].Coagulation play roe in is chemic heart disease ,increase plasm a level so coagulation in are associated with an increased risk of my ocarina infarction The orthro in time alone is derived from measures of prothrombin in ratio{PR}and intermate on abnormalized ratio{INR] are essays evaluating the extrinsic pathway bayan dc ammonal way of coagulation. They are used to determine the clotting tendency of blood in homes of war farinose[2]. The role of blood clotting activation such as elevated circulating level of Amar cero fathom Bing enervation and fibro in peptide A in the occurrence of angina in I s chemic heart disease[3].Activated thromboplastin tin time issued to monitor the effects of the part non intrinsic pathways and detect defects in factors XII, XI, IX, VIII, and the common pathway .This study concluded that serum levels of iron ,ferret in ,TI, BC ,PT ,and PTT may be associated with is chemic heart disease.
dc.identifier.urihttps://ds.eaeu.edu.sd/handle/10.58971/401
dc.language.isoother
dc.publisherجامعة الشيخ عبدالله البدري
dc.titleEvaluation of Iron Profiles and Coagulation Profiles in Ischemic Heart Diseases Patients in Elmer Nimr Hospital, Sudan
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Evaluation_of_Iron_Profiles_and_Coagulation_Profil.pdf
Size:
310.56 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
Thesis