MOA Duplication & Deletion Theory: COVID-19 Pathogenesis Mechanism: Gene Duplication, Retrotransposition, 4p15.1-pter Duplication and a 4q35.1-qter Deletion in a Recombinant of Chromosome 4 Pericentric Inversion
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Date
2020-04-22
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جامعة الشيخ عبدالله البدري
Abstract
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome Coronavirus
2 (SARS-CoV-2). It is affecting 213 countries and territories around the world. The disease causes respiratory illness
(like the flu) with symptoms such as a cough, fever, and in more severe cases, difficulty breathing, cardiac problems were
also observed in many COVID-19 patients.We theorize that COVID-19 induce mutation in chromosome 4 lead to
4p15.1-pter Duplication and a 4q35.1-qter Deletion , and the neurological and cardiac disorders observed among infected
persons resulted from retrotransposition mechanism of gene duplication occur in the specified region of chromosome 4
mentioned above. Genetic studies to chromosome 4 of COVID -19 patients recommended to confirm MOA duplication
and deletion theory (4p15.1-pter Duplication and a 4q35.1-qter Deletion).