Detection of Carbapenem Resistance among Enterobacteriaceae Pathogens Isolated from Clinical Samples in Shendi locality
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Date
2023-11-30
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جامعة الشيخ عبدالله البدري
Abstract
Abstract: Introduction: The majority of antimicrobial agents are ineffective against
carbapenem-resistant Enterobacteriaceae (CRE) infections, leading to unfavorable
clinical consequences. This fact is associated with higher mortality and morbidity rates,
prolonged hospital stays, and increased treatment-related costs. Carbapenems are the last
line for the treatment of infection caused by bacteria resistance to a broad spectrum of
antibiotics. Objective: This study aimed to detect the Distribution of Carbepanems
Resistance in Enterobacteriaceae Pathogens Isolated from Clinical Samples in the
Shendi locality. Methods: A cross-sectional study and a laboratory-based study were
carried out on 63 isolates from different specimens, 63 types of pathogenic bacteria were
isolated and identified using Gram stain, biochemical reactions, and testing for their
susceptibility to Carbapenems antibiotics was performed for all Enterobacteriaceae
isolates. Result: The isolated Enterobacteriaceae comprising of 19.0(30.2%) E.coli, 17
(27.0%) K. pneumoniae, 13(20.6%) P. vulgaris, 5(7.9%) P. mirabilis, 1(1.6%)
Enterobacter species, 3(4.8%) C. freundii and 5(7.9%) M. morganii. Carbapenem
(Imipenem and meropenem) susceptibility testing showed that 36.0% of
Enterobacteriaceae isolates were Carbapenem-resistant. Conclusions: The study
revealed the low resistance pattern of Enterobacteriaceae to Carbapenems. Despite that
E.coli (19.0, 30.0%) was the most isolated organism, and K. pneumonia (7.0, 11.0%)
was the most resistant isolate to Carbapenems. The urine sample had the highest degree
of resistance. There was a correlation between patients with chronic diseases such as
cancer and the resistance level to Carbapenems, while there was no statistical
significance between the period of antibiotics usage and the degree of resistance.