Perspective of Aryl Hydrocarbon Receptor Exhaustion as Cancer Causative
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Date
2020-04-22
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Publisher
جامعة الشيخ عبدالله البدري
Abstract
Over the last decade, Aryl Hydrocarbon Receptor (AHR) dragged the research community’s attention due to the
associated benefits in physiology and pathology. In this study, the probable role of AHR in cancer development is
discussed. The ABCG2 gene that regulates uric acid metabolism is controlled by AHR. The study noticed that the
failure of AHR control over ABCG2 leads to the accumulation of uric acid, reduction of vitamin D, and hormonal
imbalances that are sequentially associated with several types of cancer. Furthermore, the location of AHR in the
cytoplasm and its role in the regulation of the development and differentiation of blood cells, makes it impacts on
overall cells of the body, while cancer genes can be transmitted through AHR receptors in the placenta to the offspring.
Overtiredness of AHR by aging, microbial, chemical, or other environmental factors escalates the risk of cancer cell
growth. Consequently, immune system dysfunction is facilitated by metastasis. Meanwhile, the Tryptophan catabolism
indicates the exhaustion of AHR. However, this hypothesis lacks experimental exploration for further validation.