Effects of Leishmania Species on Immune Response against Malaria Parasite in Malaria Leishmania Coinfections
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Date
2021-12-08
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Publisher
جامعة الشيخ عبدالله البدري
Abstract
Both malaria and leishmania are most widespread protozoon parasitic diseases, certainly in
tropical countries of the world. Malaria leishmania coinfection is common in leishmaniasis endemic
areas which is mostly endemic to malaria too.
Researchers notice that in cases of malaria leishmania coinfection , leishmania species find the
some extent the outcome of malaria infection , but also behavior of malaria parasite species play a
significant role to figure the consequences of it. While L. donovani protect from severe malaria
complications by suppression of major histocompatibility class Ⅱ , so it diminish the clinical severity
of malaria but not malaria parasite density due to dysfunction of major histocompatibility class I,
which controlled by suppressed one, In another side L. mexicana tends to sequester in
macrophages and lead to severe clinical outcomes when it coexisted with malaria parasite at same
host. Experimental studies required to know more information about coinfection of different malaria
and leishmania species to establish clinical research.
Leishmania infection excluded when studies aim to assess the immune response to only
malaria parasite, experimental studies required involving different species of malaria and
leishmania.