Evaluation of Prothrombin Time Activated Partial Thrombo- plastin Time and Fibrinogen Level in Diabetic Pregnant Women in Shendi Town, Sudan
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Date
2023-09-01
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جامعة الشيخ عبدالله البدري
Abstract
Abstract
Background: Pregnancy is a unique physiological event that might have an impact on a woman›s coagulation and
fibrinolytic system. Pregnant women and fetuses may be at risk for thrombotic and bleeding problems due to an
abnormally hypercoagulable state during diabetic pregnancy. Thus, pregnant women must have regular coagulation tests
to keep track of their coagulation and fibrinolytic systems.
Objective: This research was carried out to analyze Prothrombin Time, Activated Partial Thromboplastin Time, and
fibrinogen level in diabetic pregnant and normal pregnant women in Shendi town in Almak Nemer hospital during the
period from June to November 2021.
Materials and Methods: In tri-sodium citrate, 150 venous blood samples total were taken, 100 from diabetic pregnant
women as cases and 50 from healthy pregnant women as controls. A questionnaire was employed to gather certain
patient-related data. Coagulometer tests were performed on blood samples.
Results: It was found that pregnant women with diabetes had a significant increase in PT and APTT but a minor increase
in fibrinogen when compared to the control result. PT and PTT values were insignificant increase with age, number of
pregnancies, and thestage of pregnancy.
Conclusions: In diabetic pregnant women, alterations in the levels of coagulation markers were seen. And the coagulation
parameter ranges were reported, which can serve as a point of reference for medical professionals to more precisely
monitor the coagulation and fibrinolytic system in pregnant diabetic patients.