Browsing by Author "Rania Saad Abdulgader"
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Item Does Hyperuricemia in Falciparum Malaria Infected Children Explains the Etiology of Burkitt’s Lymphoma?(جامعة الشيخ عبدالله البدري, 2022-04-20) Mosab Nouraldein Mohammed Hamad; Sufian Khalid M. Noor; Rania Saad Abdulgader; Awadalla H KashifAbstract: Falciparum malaria still represents the big obstacle to communities in Sub-Sahara African countries and more concentrated efforts against COVID-19 pandemic, may influence the lives of millions of children in that malaria endemic area. Hyperuricemia associated with plasmodium falciparum infection reflects the density of parasitemia and it may lead to kidney injury, resulting in low vitamin D production. Furthermore, hyperuricemia leads to high levels of proinflammatory cytokines counting interferon γ-induced protein, which is invested vitamin D deficiency in the development of Burkitt’s lymphoma. Experimental research is required.Item The Role of Aryl Hydrocarbon Receptor in Malaria Immunity during Adulthood, Childhood and Pregnancy: A Review(جامعة الشيخ عبدالله البدري, 2021-12-28) Mosab Nouraldein Mohammed Hamad; , Bader Saud Alotaibi; Rania Saad Abdulgader; , Sufian Khalid M. Noor; , Rimma Chanysheva; Awadalla H. KashifMalaria is most prevalent parasitic disease, it caused by coccidian parasite of the genus plasmodium, four species are usually infect human beings, P. falciparum, P. vivax, P. malriae and P. ovale, Most of malaria cases resulted from P. falciparum and P. vivax. Aryl hydrocarbon receptor (AHR) is an environmental sensor exists in many parts of human body such as lung, spleen, gut and breast. In this review we discussed the functions of it as regulator for proinflammatory and antiinflammatory cytokines, the possible role of diet during pregnancy and breastfeeding in boosting immunity against malaria during pregnancy and childhood by triggering AHR. Also we hypothesize that probable role of it in synchronizing erythrocytic schizogongy. Experimental studies recommended to know more about the biological protective functions of AHR.