Browsing by Author "Mosab Nouraldein Mohammed Hamad4"

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    Evaluation of Fibrinogen level and Platelets Parameters in Patients with Covid-19 Infection in Atbara Town
    (جامعة الشيخ عبدالله البدري, 2023) Mathany Backri Ahmad Dow1; Mohammed Osman Ali Mohammed1; Lana Jamal Abubaker2; Ghanem Mohammed Mahjaf2; Fania A Albadri3; Mosab Nouraldein Mohammed Hamad4
    Abstract: Background: COVID-19 can cause various conditions, including respiratory, enteric, and neurological diseases, and led to the pandemic that has affected millions worldwide. Methods: This is a cross-sectional descriptive prospective study conducted at Atbara Teaching Hospital, which is located in Atbara town in Sudan, to determine the fibrinogen level and platelet count and platelet indices in patients with COVID-19 infection during the period between June and December 2021. A total of 100 patients who were diagnosed with the COVID-19 infection were enrolled in this study as test groups, with 50 healthy volunteers serving as a control group. Venous blood samples were collected from the test and control groups and transferred into Tri sodium citrate for measurement of fibrinogen levels and EDTA anticoagulant for analysis of platelet parameters. Results: The means of fibrinogen level, platelet count, PDW, and MPV in the test group were 147.63 md/dl, 274.90 x 109 /l, 14.587 FL, and 9.214 FL) respectively. The means of fibrinogen level, platelet count, PDW, and MPV in the control group were (163.86 md/dl, 332.46 x 109 /l, 15.426 FL, and 7.982 FL) respectively. Also, statistical analysis showed that there was significant variation in fibrinogen level, PDW, and MPV in a patient with COVID-19 when compared with healthy individuals. Low fibrinogen levels in COVID-19 patients may be due to an increased risk of thrombosis, so a greater degree of fibrinogen consumption occurs in COVID-19. Conclusions: This study concludes that COVID-19 patients are at high risk of thrombosis because their blood tests reveal low fibrinogen levels. This study also concludes that there was thrombocytopenia in COVID-19 patients when their results showed a decrease in platelet distribution width and an increase in mean platelet volume.
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    In vitro Assessment of Antimicrobial Activity of Honey Bees and Nigella sativa Against Selected Clinical Isolates from Shendi City
    (جامعة الشيخ عبدالله البدري, 2022-03-16) Ghanem M Mahjaf; Leila M Abdelgadeir; Aisha Y Ibrahim; Nedal A Mohammed; Sulafa A Mohammed; Salih O Mohammed; Mosab Nouraldein Mohammed Hamad4; Naser E Bilal
    Abstract Background: An alarming rise in bacterial strains resistant to existing antimicrobial agents requires a renewed effort to seek agents effective against pathogenic bacteria resistant to antimicrobials. The new antimicrobial agents are will overcome this problem. Objective: This study aimed to study the in vitro antimicrobial activity of different concentrations of Honey, petroleum ether extracts of medicinal plant Nigella sativa (seeds), and the mixture using the cup-plate agar diffusion method. Materials and Methods: This cross-sectional observational study was carried out among One hundred samples were collected from urine, wound, ear, and eye swab, 95/100 (95%) showed bacterial growth, from which six types of pathogenic bacteria at Shendi city hospitals during March to June 2018. Results: Of the total 95 clinical and standard specimens were confirmed as Staphylococcus aureus 20 (21%), Escherichia coli 20 (21%), Pseudomonas aeruginosa 15 (16%), and Klebsiella pneumoneae 30 (31%). In addition to Candida albicans 10 (11%). These results showed the activity of antimicrobial Petroleum ether extract of the Nigella sativa, and honey pronounced dose-dependent on standard strains and clinical isolates, while methanolic extract of Nigella sativa explained no activity. Conclusion: The activity of Nigella sativa, honey, and the mixture exhibited high antimicrobial activity against all types of tested or ganisms both clinical and standard organisms. Therefore Nigella sativa, honey, and the mixture can be regarded as a broad-spectrum antimicrobial agent.