Browsing by Author "Ghanem Mohammed Mahjaf2"

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    Detection of secretor gene among Sudanese patients with chronic renal failure in Shendi town: A cross sectional study
    (جامعة الشيخ عبدالله البدري, 2023) Nazzla Abd Alhameed H. Mohammed1; Elfatih Mohammed A. Ali1,; Alaa Babiker H. Alkab1; Ghanem Mohammed Mahjaf2; Tibyan Abdalmajed Altaher3; Mosab Nouraldein Mohammed Hamad4*
    Abstract: Background: Secretor status is valuable with some diseases in clinical and forensic medicine. Objectives: This study aimed to evaluate the status of secretors and non-secretors in chronic renal failure patients under hemodialysis in Shendi town at the kidney treatment and surgery center (Sudan). Method: Saliva samples were collected from fifty patients (58% were male) aged from 15 to 65 years and secretor status was studied by the hemagglutination inhibition method of saliva. Result: results showed that 68% of the study population were non-secretors. probable frequency of the Se and se genes was 17,6% and 82,4% while the frequency of SeSe, Sese, and sese allele genes was 3%, 29%, and 68% respectively. were calculated by utilizing Hardy-Weinberg Theorem for probabilities and possibilities. Frequencies of the non-secretor status among various ABO blood groups were 63.2% in group A, 75% in group B, and 72.7% in group O. Conclusion: We conclude that non-secretors are more prevalent in chronic renal failure. In the present study observed that non-secretors were more common as compared to secretors, non-secretors are more prone to renal failure.
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    Evaluation of Fibrinogen level and Platelets Parameters in Patients with Covid-19 Infection in Atbara Town
    (جامعة الشيخ عبدالله البدري, 2023) Mathany Backri Ahmad Dow1; Mohammed Osman Ali Mohammed1; Lana Jamal Abubaker2; Ghanem Mohammed Mahjaf2; Fania A Albadri3; Mosab Nouraldein Mohammed Hamad4
    Abstract: Background: COVID-19 can cause various conditions, including respiratory, enteric, and neurological diseases, and led to the pandemic that has affected millions worldwide. Methods: This is a cross-sectional descriptive prospective study conducted at Atbara Teaching Hospital, which is located in Atbara town in Sudan, to determine the fibrinogen level and platelet count and platelet indices in patients with COVID-19 infection during the period between June and December 2021. A total of 100 patients who were diagnosed with the COVID-19 infection were enrolled in this study as test groups, with 50 healthy volunteers serving as a control group. Venous blood samples were collected from the test and control groups and transferred into Tri sodium citrate for measurement of fibrinogen levels and EDTA anticoagulant for analysis of platelet parameters. Results: The means of fibrinogen level, platelet count, PDW, and MPV in the test group were 147.63 md/dl, 274.90 x 109 /l, 14.587 FL, and 9.214 FL) respectively. The means of fibrinogen level, platelet count, PDW, and MPV in the control group were (163.86 md/dl, 332.46 x 109 /l, 15.426 FL, and 7.982 FL) respectively. Also, statistical analysis showed that there was significant variation in fibrinogen level, PDW, and MPV in a patient with COVID-19 when compared with healthy individuals. Low fibrinogen levels in COVID-19 patients may be due to an increased risk of thrombosis, so a greater degree of fibrinogen consumption occurs in COVID-19. Conclusions: This study concludes that COVID-19 patients are at high risk of thrombosis because their blood tests reveal low fibrinogen levels. This study also concludes that there was thrombocytopenia in COVID-19 patients when their results showed a decrease in platelet distribution width and an increase in mean platelet volume.
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    Prevalence and Antimicrobial Susceptibility Testing of Salmonella and Shigella Species among Children with Diarrhea in Khartoum and Al Jazeera States, Sudan
    (جامعة الشيخ عبدالله البدري, 2023) Hadia Babiker Abdelbaset1; Abdelnour A. Haroun1; Makki A. Ibrahim1; Mohammed A. Mohammed1; Mayada S. Mohammed1; Talal B. Alhussin1; Ghanem Mohammed Mahjaf2; Mosab Nouraldein Mohammed Hamad3*
    Abstract: Background: It has been estimated that in low and middle-income countries (LMICs) each child suffers up to 15 to 19 episodes of diarrhea per year. Diarrhea kills more young children than Malaria, AIDS, and Measles combined a large proportion of which were attributed to Salmonella and Shigella spices. In developing countries, Salmonella and Shigella species remain major contributors to acute enteric infection in children. Objectives: To detect the prevalence of Salmonella and Shigella species and antibiotic susceptibility testing among children with diarrhea in Khartoum and Al Jazeera states, Sudan (2022). Methods: A descriptive, prospective cross-sectional study was carried out from July to October 2022 among 120 children with diarrhea aged 3-14 years in Khartoum and Al Jazeera states. Information about patient demographics and clinical status was obtained from each patient using a written questionnaire. Stool specimens from diarrheic children were collected and processed for wet mount examination and isolation of Salmonella and Shigella using conventional microbiology procedures. Antibiotic susceptibility patterns were determined by using the Kirby-Bauer disc diffusion method through culturing the isolates on Mueller- Hinton agar. The collected data and laboratory results were analyzed using SPSS version 26. Results: In this study; only 2/120 (1.7%) of the specimens showed growth of Shigella sonnei and Shigella species both were isolated from patients from Al Jazeera state (Al Sameer village), both Shigella isolates were sensitive to ciprofloxacin, gentamicin, cefotaxime, amikacin and only resistant to amoxicillin. G. lamblia and E. histolytica were detected in wet mount examination in stool specimens with a prevalence of (8.3%) and (4.2%) respectively. In our study, there was no association between positive stool culture and type and duration of diarrhea, symptoms with diarrhea, hospitalization, household income, source of drinking water, and hand washing. Conclusion: In this study, only Shigella was detected 2/120 (1.7%) among children aged 3-14 years suggesting the dominance of other causes of diarrhea including intestinal parasites. A further study targeting other causes of diarrhea should be conducted to establish the major causes of diarrhea in children in the study areas