Browsing by Author "Abdelhalim Nasr"

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    Natural Inhibitor; Antithrombin and Protein S Levels among Neonates Suffering from Sepsis
    (جامعة الشيخ عبدالله البدري, 2021-01-01) Albara Ahmed; Babiker Mohammed; Abdelhalim Nasr; Awadelkarim Abbas; Mosab Nouraldein Mohammed Hamad
    Abstract Neonatal sepsis is a fatal disease with significant neonatal morbidities and mortalities worldwide, despite preventive measures and efforts that target neonatal sepsis, morbidity and mortality statistics were not promising. Common clinical symptoms of sepsis make earlier diagnosis challenging. Objectives: the study aimed to assess antithrombin (AT) and Protein S (PS) among Sudanese neonates with sepsis and compare them with healthy neonates to study the susceptible alteration in both natural inhibitors of hemostasis (AT and PS) considering different variables (gender, mode of delivery, gestational age, sepsis mode, outcome and causative bacterial agent Methods: a prospective case-control study achieved in the maternity hospital, Omdurman, Sudan in the period between Jun.2013 and Apr.2015 on a total of 100 samples divided into the case (neonates diagnosed with proven sepsis) and a control group of health neonates (50 for each) selected by non-probability sampling, Protein S was assessed by the clotting procedure using semi-automated coagulometer (Stago stat four), AT was assessed spectrophotometrically by the turbimetric method using semi-automated chemistry analyzer (Mindray BA-88A). Results: the gender distribution was 23, 27 and 24, 26 males and females for case and control respectively, among case group; 17 neonates with early mode sepsis (0-7 days), and 33 with late onset (7-28 days). Considering the outcome in case group; 40 were recovered (80%) and 10 neonates dead (20%) of them; 4 (40%) with early onset sepsis, and 6 (60%) with late onset. Blood culture distributions were; Pseudomonas 23 (46%), Salmonella 9 (18), Klebsiella 7 (14%), Staph. epidermidis 3 (6%), Strep. fecailis 3 (6%), E. coli 2 (4%), Staph. aureus 2 (4%), and 1 Streptococci (Non group B) (2%). AT was significantly decreased in the case compared to the control group (mean; 183.9 and 221.5 Mg/ml) P. value 0.003. PS was insignificantly decreased (33.4 and 34.7%) P. value 0.76. Among the case group; None of the gender, mode of delivery, Mode of sepsis, etiologic agent and sepsis outcome showed significant correlation with AT or PS. Conclusion: it has been concluded that antithrombin was significantly decreased in septic neonates than healthy ones (P. value 0.003). It can be used as a diagnostic marker to offer quick reliable useful test feedback for septic neonates.
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    Protein C Level and Activated Partial Thromboplastin Time in Neonatal Sepsis
    (جامعة الشيخ عبدالله البدري, 2020-02-07) Albara Ahmed; Babiker Mohammed; Abdelhalim Nasr; Wafa Elhag; Awadelkareem Abass; Mosab Nouraldein Mohammed Hamad
    Abstract Aim: The researchers intended to evaluate Activated Partial Thromboplastin Time (APTT) and Protein C (PC) amongst Sudanese neonates with sepsis (Cases) in Omdurman maternity hospital, Sudan related with healthy neonates (controls) for recognizing haemostatic alteration in APTT and PC amongst neonatal sepsis which cumulative yearly in Sub Saharan African countries along with incessant home-grown efforts by governmental bodies and NGOs. Results: An overall of 100 neonates alienated similarly into septic cases and healthy controls, died neonates were constituted 10 (20%) while 40 (80%) were recovered between case group. APTT showed noteworthy continuation in septic neonates compared to controls (mean; 47.8 and 37.5 sec for cases and controls, respectively) P-value was 0.00. Amongst patients group: dead neonates exhibited significant prolongation matched recovered (mean; 61.5 and 44.4 sec) P-value 0.00. PC showed noteworthy reduction in dead neonates compared to recovered (mean; 25.4 and 36.2% for dead and improved). P-value 0.04. Insignificant change in PC was found amid case and control group. None of the sex, gestational age, delivery method, sepsis onset, and causative agent displayed noteworthy correlation with APTT and PC. APTT&PC can be valuable as indicator of neonatal sepsis mortality. Conclusion: APTT was meaningfully prolonged in neonatal sepsis (P-value 0.00). APTT also prolonged considerably in deceased septic neonates matched to recovered one (P-value 0.00). PC reduced expressively in dead neonates compared to recover in case group (P-value 0.04). Prolonged APTT and reduce PC can be valuable as a marker for neonatal sepsis mortality.