Protein C Level and Activated Partial Thromboplastin Time in Neonatal Sepsis

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جامعة الشيخ عبدالله البدري
Abstract Aim: The researchers intended to evaluate Activated Partial Thromboplastin Time (APTT) and Protein C (PC) amongst Sudanese neonates with sepsis (Cases) in Omdurman maternity hospital, Sudan related with healthy neonates (controls) for recognizing haemostatic alteration in APTT and PC amongst neonatal sepsis which cumulative yearly in Sub Saharan African countries along with incessant home-grown efforts by governmental bodies and NGOs. Results: An overall of 100 neonates alienated similarly into septic cases and healthy controls, died neonates were constituted 10 (20%) while 40 (80%) were recovered between case group. APTT showed noteworthy continuation in septic neonates compared to controls (mean; 47.8 and 37.5 sec for cases and controls, respectively) P-value was 0.00. Amongst patients group: dead neonates exhibited significant prolongation matched recovered (mean; 61.5 and 44.4 sec) P-value 0.00. PC showed noteworthy reduction in dead neonates compared to recovered (mean; 25.4 and 36.2% for dead and improved). P-value 0.04. Insignificant change in PC was found amid case and control group. None of the sex, gestational age, delivery method, sepsis onset, and causative agent displayed noteworthy correlation with APTT and PC. APTT&PC can be valuable as indicator of neonatal sepsis mortality. Conclusion: APTT was meaningfully prolonged in neonatal sepsis (P-value 0.00). APTT also prolonged considerably in deceased septic neonates matched to recovered one (P-value 0.00). PC reduced expressively in dead neonates compared to recover in case group (P-value 0.04). Prolonged APTT and reduce PC can be valuable as a marker for neonatal sepsis mortality.