Mohammed Bahreldin Hussein,Mosab Nouraldein Mohammed Hamad2023-11-272023-11-272020-09-28https://ds.eaeu.edu.sd/handle/10.58971/552Abstract Schiff bases are the most widely used organic compounds. They have been shown to exhibit a broad range of biological activities, including; antifungal, antibacterial, anti malarial, anti-proliferative, anti-inflammatory, antiviral, and antipyretic properties. In this study semicarbazone ligand was prepared by condensing 3-nitropenzaldehyde with semicarbazide hydrochloride in 1:1 molar ratio in ethanolic medium. This ligand was used to synthesize metal complexes of copper (II) and nickel (II) in 1:2 molar ratio using ethanol as a solvent .Characterization and structure elucidation of prepared metal complexes have been investigated on the basis of molar conductance and UV and IR spectral studies. The all prepared compounds showed a vital effect against both types of bacteria gram positive (Staphylococcus-aurous) and gram negative (Escherichia-coli).other