Mosab Nouraldein Mohammed Hamad2023-12-262023-12-262023-12-26Mosab Nouraldein Mohammed Hamad; “Hypothesis: Gastric Acidity as a Possible Cause of Antimalarial Failure in Sudan” Middle East Res J. Microbiol Biotechnol., 2023 Nov-Dec 3(2): 54-55.DOI: 10.36348/merjmb.2023.v03i02.006https://ds.eaeu.edu.sd/handle/10.58971/915Malaria is an endemic disease in Sudan and represent one of major health problems influencing the fragile economy of the country, as many protocols established there, but still malaria cases exaggerated, certainly after the current conflicts between army and the paramilitaries. Wars, poverty, and their social consequences increase stress among local population, which regarded as on of the main causes of acidity, besides malnutrition, wrong feeding behavior and opportunistic infections with certain bacteria such as H. pylori and some fungi like overgrowth of candida species may elevate the blood acidity. Unfortunately, acidity affect absorption of antimalarials, then we suggested that usage of antiacids should preceed ingestion of antimalarial tabs to enhance its absoption, in order to clear malaria parasite from blood. Luckily, antiacids releive acidity of microbial origin, which is attibuted to candidal overgrowth or H. pylori infection, and then as we mentioned above increase clearance of plasmodium. Patient history of recurrent gastric acidity, stool analysis, H. pylori test and blood PH are recommended to avoid treatment failure of malaria patient. Besides antimalarial misuse among our local population in Sudan we suggested that gastric acidity is the one of the main reasons of antimalrial protocols failure in Sudan, specifically after choloroquine resistance. We hypothesized that usage of antiacids prior to administration of antimalarial drug will promote the effectiveness of antimalarialsenArticle