Mosab Nouraldein Mohammed Hamad2023-12-102023-12-102019-03-17https://ds.eaeu.edu.sd/handle/10.58971/740Abstract Entamoeba coli is a neglected intestinal amoeba, mostly occur in the tropical African countries. This species of amoeba transmit through feco-oral route, through ingestion of cyst form, which is responsible for infection and then it transforms into trophozoite stage which is pathogenic form. Most of scientists regard Entamoeba coli as a commensal intestinal amoeba, although of their bad impact on human health , it may lead to diarrhea , constipation , abdominal pain, fatigue and may lead to serious complications such as heart diseases due to electrolytes imbalance and accumulations of cholesterol and low density lipoprotein also they affect the bleeding profile. Additional studies must be conducted to reclassify this amoeba from commensal into pathogenic intestinal amoebaother