Mosab Nouraldein Mohammed HamadHisham Abd alhameed Ibn Idris, Amna A. Alameen, Fatima A. NaserOmnia M. Ahmed, Razan S. AbdullaSara M. AlhajTibyan A. Shareef, Ghanem Mohammed MahjafMosab Nouraldein Mohammed Hamad2023-11-202023-11-202023https://ds.eaeu.edu.sd/handle/10.58971/371Abstract Smoking use is widely spread throughout the world. The effect of smoking on human health are serious and, in many cases, deadly. This is a cross-sectional study conducted during the period from April 2018 to measure ALT & AST activities between smokers and nonsmokers. Thirty smokers were selected as the test group and thirty nonsmokers as the control group (age was matched (30-65)). Blood specimens were collected from both groups, and serum ALT &AST activities were determined by using an auto-analyzer (Mindary). Insignificant in means of serum AST &ALT activities in smokers when compared to the control group. The results also showed an insignificant correlation between age and serum AST&ALT activity. Statistical analysis also showed an insignificant correlation between the duration of smoking and serum AST&ALT activity. The result also showed an insignificant correlation between the number of cigarettes per day and serum AST & ALT. No correlation between AST & ALT activities with duration of smoking per year, no correlation between AST & ALT activities with age, and no correlation between AST &ALT activities with several cigarettes per day.other