Diabetic Nephrophathy in patients with diabietes mellitus type-2
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Date
2022-02
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جامعة الشيخ عبدالله البدري
Abstract
Abstract
Kidney Function assessment is important in diabetic patients and early
detection of diabetic nephropathy in preclinical stage of disease will
contribute to decreasing morbidity and mortality rates.
This study focused on the determination of risk factors that may lead to
diabetic nephropathy in type-2 DM patients in Khartoum state.
Early morning urine samples and blood samples were collected from 50.
diabetic patients, their age range was from 30-65years. All the 50 subjects did
not suffer from urinary tract infection, heart, liver or renal diseases.
Micro albumin measured in urine samples using Immunoturbidimetric method
to show an early indication of deteriorating renal function and increased
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vascular permeability. While HbAlc was assayed using Labona Check Alc
HbA1c Analyzer. Lipid profile was assayed using colorimetric assay kits.
Microalbumin concentration showed significant differences between diabetic
patients, where 58%of the study group shown elevated MAU (diabetic
nephropathy)38% of them are males and20% are females, and 42% of study
group without elevated Microalbumin (non-nephropathy) 14% of them are
males and 28%of them are females. Furthermore, the study showed
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significant difference (PV=<0.05) in blood pressure (systolic and diastolic),
T. cholesterol, TG, and LDL between nephropathy and non-nephropathy
groups, which indicate these markers have influence in appearance of MAU
in diabetic patients.
There was insignificant difference in age, duration of DM, BMI, HDL, and
glycemic control between nephropathy and non-nephropathy.
The study concluded that lipid profile and high blood pressure can cause
complications in Sudanese patients with type -2DM like nephropathy.