Alteration of Coagulation Parameters in Plasmodium Falciparum Malaria Patients and its Correlation with Degree of Parasitaemia in Khartoum state Sudan; 2019
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Date
2019-12-30
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جامعة الشيخ عبدالله البدري
Abstract
Background: The hemostatic alterations play an important role in malaria pathogenesis and in the progression of disease.
In severe infection the accelerated coagulation cascade activity with accelerated fibrinogen turnover increase the bleeding
tendency and may lead to DIC. Objectives: This study was aimed to determine the Alteration of coagulation parameters
in Plasmodium Falciparum malaria Patients and its correlation with degree of parasitemia in Khartoum state. Sudan;
2019. Material and method: Analytical cross sectional study, 170 blood samples were enrolled in this study.85 samples
of blood were collected from patients with falciparum malaria and 85 samples were collected from healthy individual as
control, then PT and APTT will be measured by coagulometer. Result: The mean of PT was significantly high in case
than in control (14.201second vs 13.668 second, (P value (< 0.01)).While there was no differences in the mean of APTT
between case and control (33.075 vs 33.192 second ) P value (0.735). Conclusions: Our study concluded that the mean
of PT was significantly higher in case than control, While there was no differences in the mean of APTT between case
and control, and There was no differences between the PT and APTT of case and control according to gender. And
there is no correlation between degree of parasitemia in PT, APTT and age.