Autophagy: fasting to be healthy
| dc.contributor.author | Mosab Nouraldein Mohammed Hamad | |
| dc.date.accessioned | 2023-12-12T07:17:48Z | |
| dc.date.available | 2023-12-12T07:17:48Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles, which are sometimes complex. Autophagy consists of several sequential steps²sequestration, transport to lysosomes, degradation, and utilization of degradation products²and each step may exert different function. This process is quite distinct from endocytosis-mediated lysosomal degradation of extracellular and plasma membrane proteins. There are three types of autophagy²macroautophagy, microautophagy, and chaperone-mediated autophagy²and the term ³autophagy´ usually indicates macroautophagy unless otherwise specified. Autophagy is mediated by a unique organelle called the autophagosome. As autophagosomes engulf a portion of cytoplasm, autophagy is generally thought to be a nonselective degradation system. This feature is in marked contrast to the ubiquitin±proteasome system, which specifically recognizes only ubiquitinated proteins for proteasomal degradation. It is therefore reasonable to assume that the ubiquitin±proteasome system has numerous specific functions because it can selectively degrade thousands of substrates. | |
| dc.identifier.uri | https://ds.eaeu.edu.sd/handle/10.58971/770 | |
| dc.language.iso | other | |
| dc.publisher | جامعة الشيخ عبدالله البدري | |
| dc.title | Autophagy: fasting to be healthy |