Diagnostic Value of Red Cell Distribution Width (RDW), Mean Platelet Volume (MPV), and Platelets Count in Sudanese Neonates with Proven Sepsis

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جامعة الشيخ عبدالله البدري
Background: Sepsis is a life-threatening clinical condition that has cost humanity heavily since time immemorial. The aim of the study was to investigate the relationship between the red blood cell distribution width (RDW), mean platelet volume (MPV) platelet count, and neonatal sepsis in Sudan. Material and Method: A prospective cross sectional hospitalized based study was conducted in Omdurman maternity hospital, in the period from June 2013 to April 2015.Hundred Sudanese neonates were grouped equally into two; case group were neonates with proven sepsis by the culture (N=50), and control group were healthy neonates (N=50). Mean Platelet Volume (MPV), red blood cell distribution width (RDW), and platelet count were performed by using hematological analyzer (KX-21 Sysmex) and the results compared between two groups. Result: Of the fifty sepsis group 23 (46%) were male, and 27(54%) were female. Whereas in control group 24 (48%) were male, and 26 (52%) were female. The mean age in case group was 9 days, and in control group was 4.3 days. The mean of platelet count was significantly lower in sepsis group than control, P value (<0.001). The mean of MPV and RDW CV were significantly higher in sepsis group than control, P. value (<0.001, and 0.026 respectively). In sepsis group, there were no significant change in MPV, RDW CV, and platelet count according to fate between died and recovered patient. Conclusions: The MPV and RDW were higher where as platelets count was lower in neonatal sepsis and these tests were inexpensive and commonly measured and may be with value in diagnosis and prognosis for neonatal sepsis. Further studies are required to determine the predicting value for MPV, RDW CV, and platelet count in neonatal sepsis.