In Vitro Antibacterial Activity of Ginger Extract (Zingiberofficinale) on Bacteria Isolated from Diabetic Patient with Urinary Tract Infections in Shendi Locality, Sudan

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جامعة الشيخ عبدالله البدري
Abstract: Background: Urinary tract infections frequently occur in diabetic patients due to an impaired immune status and increased glucose content in the urine among other reasons. This makes UTIs very important to investigate. Complicated cases of UTI may be frequent but are more common in diabetics with more severe consequences. And so warrant further investigations. The proper management of UTI in diabetics is crucial as prompt diagnosis and correct use of antibiotics are vital for treatment. Finding alternative antimicrobial agents from plant extracts has received growing interest. Ginger (Zingiberofficinale) is a safe, non-toxic, cheap spice that has been reported to have antimicrobial effects against various pathogenic bacteria. Objectives: This study aimed to evaluate the effectiveness of ginger extract on different types of bacteria isolated from diabetic patients suffering from urinary tract infections. Methodology: A cross- sectional and hospital-based study has been conducted at the University of Shendi –faculty of medical laboratory sciences- department of microbiology from May to November 2018. Following informed consent, 100 diabetic patients suffering from UTI of different ages were enrolled in this study. Sixty-two bacteria were isolated, different Gram- positive and Gram-negative bacteria, in vitro sensitivity testing using a well diffusion technique against ginger extract. Results: The main causative agent of UTI in the study population was E. coli 32.3% then S. aureus 29%, S. saprophyticus 29%, and E. faecalis9.7%. The largest diameter of the inhibition zone appeared in Gram-positive S.saprophyticus (13.4mm). The concentrations of ginger extract used were 100, 50, 25, and 12.5 mg/ml. mean of inhibition zone of chloramphenicol for isolated bacteria S.aureus 31mm, S.saprophyticus 20.2 mm, E.coli 17.7mm, and faecalis24.6mm. Conclusion: The antimicrobial activity of the crude extract was compared with that of standard antimicrobial chloramphenicol based on the mean diameter of the inhibition zone. The extract exhibited maximum relative percentage inhibition against S.saprophyticus(42.3%) and minimum relative percentage inhibition against S. aureus (6.3%)