Assessment of Oral Cellular Proliferative Activity among Toombak Users in Berber City 2017

Abstract
Many factors have been identified as important causative agents that responsible for the development of oral precancerous and cancerous lesions in Sudan. Toombak have been identified as a major risk factor therefore the aim of this study was to assess the cellular proliferative activity that associated with Toombak use. In this study 90 healthy individuals were selected for this study of whom76 were Currently Toombak users and 14were non Toombak users. Result: cytological atypia was identified as: Per nuclear hallo, Bactria infection, irregular, high N\C ratio, poly morph, keratinization, inflammation and nuclear atypia. The mean count NORs count was 3.2 in cases and 1.2 in controls. Conclusion: Toombak is a major risk factor for occurrence of cellular proliferative activity features that may progress in to oral precancerous or cancerous lesions تم تحديد العديد من العوامل المسببة المهمة والمسؤول عن تطور الاورام السرطانية . في السودان يعتبر التمباك من اكثر المخاطر لسرطان الفم . لذلك تهدف هذه الدراسة الي تقيم النشاط الخلوي لمستخدمي التمباك في هذه الدراسة م اختيار 90 شخصا منهم 14 شخص لا يتعاطون التمباك و 76 شخص يتعاطون التمباك استخدمت طريقتي باب والسلفر لصبغ المسحات الخلوية تم تحديد متوسط النمطية الخلوية للحالات عينات التي صبغت بال Ag-NORهي3,2للحالات 1,2للضوابط.
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