Determination of Risk Factors of Diabetic Nephropathy in Sudanese Patients with Diabetes Mellitus Type-2 Khartoum State

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جامعة الشيخ عبدالله البدري
Abstract Kidney Function assessment is important in diabetic patients and early detection of diabetic nephropathy in preclinical stage of disease will contribute to decreasing morbidity and mortality rates. This study focused on the determination of risk factors that may lead to diabetic nephropathy in type-2 DM patients in Khartoum state. Early morning urine samples and blood samples were collected from 50 diabetic patients, their age range was from 30 - 65 years. All the 50 subjects did not suffer from urinary tract infection, heart, liver or renal diseases. Micro albumin measured in urine samples using Immunoturbidimetric method to show an early indication of deteriorating renal function and increased vascular permeability. While HbAlc was assayed using Labona CheckTMA1c HbA1c Analyzer. Lipid profile was assayed using colorimetric assay kits. Microalbumin concentration showed significant differences between diabetic patients, where 58% of the study group shown elevated MAU (diabetic nephropathy) 38% of them are males and 20% are females, and 42% of study group without elevated Micro albumin (non-nephropathy) 14% of them are males and 28% of them are females. Furthermore, the study showed significant differ ence (PV = < 0.05) in blood pressure (systolic and diastolic), T. cholesterol, TG, and LDL between nephropathy and non-nephropathy groups, which indicate these markers have influence in appearance of MAU in diabetic patients. There was insignificant difference in age, duration of DM, BMI, HDL, and glycaemic control between nephropathy and non-ne phropathy. The study concluded that lipid profile and high blood pressure can cause complications in Sudanese patients with type-2DM like nephropathy