Detection of Antifungal Activity of Cinnamon Extract on Candida Species Isolated from Diabetic Patients with Urinary Tract Infection Pre-COVID-19 Era

Abstract

Abstract: This study aimed to evaluate the antifungal activity of Cinnamon extract on Candida species isolated from 100 diabetic patients suffering from urinary tract infection between May to August 2018. Twenty-five Candida species were isolated, different Candida species were isolated then identified biochemically, in vitro sensitivity testing using well diffusion technique against Cinnamon extract was done. The cinnamon extract showed good antifungal activity against Candida species. The largest zone of inhibition against Candida tropicalis was (25 mm) and the least zone of inhibition was against Candida kefyr was (10 mm). The results of antimicrobial activity of crude extract were compared with the positive control (Clotrimazole) for evaluating their relative percentage inhibition and statistical significance the aqueous extract exhibited maximum relative percentage inhibition against Candida kefyr (89%) and minimum relative percentage inhibition against Candida glabrata was (12.3%). The p. values (0.018) are statistically significant.