Evaluation of Iron Profiles and Coagulation Profiles in Ischemic Heart Diseases Patients in Elmek Nimir Hospital, Sudan
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Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
جامعة الشيخ عبدالله البدري
Abstract
Abstract
Background: Ischemic heart disease (IHD) isa constellation of diseases that includes stable angina, unstable angina,
myocardial infarction, and sudden cardiac death. It belongs to the group of cardio vascular diseases and is the most
common type among them. Iron is an essential trace element. It plays an important role in maintaining various cellular
function sand enzymatic reactions. On the other hand, excessive intake of iron is known to be a risk factor for the
progression of atherosclerosis. Abnormal iron deposition in the heart causes hemochromatosis and dilated
cardiomyopathy, which leads to ischemic heart disease. Objective: This study aims to investigate the role of serum iron,
serum ferritin, total iron-binding capacity (TIBC), PT, and PTT in ischemic heart disease (IHD)and their relationship with
other risk factors for IHD.
Methods: This is a prospective, case-control, cross-sectional analytical studyconducted at Elmek Nimir University Hospital,
Shendi City, to assess they are on profile and coagulation profile of patients with is chemic heart disease. The study
included (30) patients diagnosed with is chemic heart disease and the study group was compared with the mean of the
control group (20). Serum iron, ferritin, and TIBC were estimated using a spectrophotometer, and PT and PTT were
estimated using manual methods. Data were collected using a structured personal questionnaire and the program (SPSS)
version (11.5) was used for data analysis.
Results: In this study, patients with are chemic heart disease were (40%) male and (60%) female. In this study, iron
averaged (41.0) ug/dl (P-value 0.010), ferritin averaged (233.0) ug/dl (P-value 0.000), and TIBC averaged (44.0) µg/dl. Was
shown. (P-value 0.000) compared to mean controls (27.0), (162.0), (56.0). A significant difference was found between them
on profile and his IHD. This study showed the mean PT, PTT for cases (13.4), (40.4) (P-value 0.024), (P. value 0.009)
compared with the mean for controls (12.0), (35.1). A significant difference was found between the coagulation profile
and IHD.
Conclusions: This studyconcluded that serum levels of iron, ferritin, TIBC, PT, and PTT may be associated with Ischemic
heart disease.