Effect of Oral Contraceptives on Coagulation Parameters among Sudanese Women in Khartoum state

Abstract

Background: The contraceptive pills are the common name for oral contraception; it's one of the safest, Methods of birth control. Objectives: To evaluate the Effect of oral contraceptives treatment on the Coagulation parameters (PT, APTT, and D-Dimer) among Sudanese women. Materials and Methods: A descriptive cross sectional study conducted at Khartoum State, Sudan, during the period of May 2018 to December 2018.sixity nine (N = 69) patients using oral contraceptive pills were included in this study. Venous blood was obtained and platelets poor plasma (PPP) prepared, then PT, APTT determined using Coagulo-analyzer. D-Dimer measured by quantitative method using Ichroma analyzer. Results: The present study showed that there was no significant differences in mean of PT in study group compared to the mean normal control (p value = 0.06) .In the other hand the mean of INR is significantly (p value = 0.04) increased in study group compared to the mean of normal value (mean = 1.05 and 1.0 respectively), whereas APTT was significantly decreased in study group (compared to the mean of normal value (mean = 31.3, 33), (p value = 0.001). But the D-Dimer was positive for 8 women (11.6%) (D-Dimer = > 10000 ng/ml). Conclusion: There was significant decrease in APTT, D-Dimer was positive in 11.6 % in contraceptive women, while there was no change in PT result in study group.