Browsing by Author "Shafie Abdulkadir Hassan"

Now showing 1 - 4 of 4
  • No Thumbnail Available
    Item
    Effects of Leishmania Species on Immune Response against Malaria Parasite in Malaria Leishmania Coinfections
    (جامعة الشيخ عبدالله البدري, 2021-12-08) Mosab Nouraldein Mohammed Hamad; Sufian Khalid M. Noor; Awadalla H. Kashif c‡,Eltayeb; Mohammed Medani; Bader Saud Alotaibi; Elizabeth Popova; Shafie Abdulkadir Hassan; Yassin Bakri Salih; Yassin Saad Elhossin; Tarig Mohammed Elfaki; Mohammed Ahmed Ibrahim Ahmed
    Both malaria and leishmania are most widespread protozoon parasitic diseases, certainly in tropical countries of the world. Malaria leishmania coinfection is common in leishmaniasis endemic areas which is mostly endemic to malaria too. Researchers notice that in cases of malaria leishmania coinfection , leishmania species find the some extent the outcome of malaria infection , but also behavior of malaria parasite species play a significant role to figure the consequences of it. While L. donovani protect from severe malaria complications by suppression of major histocompatibility class Ⅱ , so it diminish the clinical severity of malaria but not malaria parasite density due to dysfunction of major histocompatibility class I, which controlled by suppressed one, In another side L. mexicana tends to sequester in macrophages and lead to severe clinical outcomes when it coexisted with malaria parasite at same host. Experimental studies required to know more information about coinfection of different malaria and leishmania species to establish clinical research. Leishmania infection excluded when studies aim to assess the immune response to only malaria parasite, experimental studies required involving different species of malaria and leishmania.
  • No Thumbnail Available
    Item
    Impact of Uric Acid in Malaria Outcomes
    (جامعة الشيخ عبدالله البدري, 2021) Mosab Nouraldein Mohammed Hamad; Yassin Bakri Salih; Sufian Khalid M. Noor; Awadalla H Kashif; Mohammed Medani Eltayeb; Bader Saud Alotaibi; Elizabeth Popova; Rania Saad Abdulgader; Abdelgadir Elamin Eltom; Shafie Abdulkadir Hassan; Tarig Mohamed Elfaki1; Mohammed Ahmed Ibrahim Ahmed
    Up to the date variations of malaria pathogenesis between human populations signify important trouble facing scholars concerned with malaria pathology. Pathogen-associated molecular patterns may be one of the main keys to the well understanding of malaria mechanism and dissimilarity of clinical outcomes of the disease between people. Uric acid is regarded as a dangerous alarming metabolite, resulting from plasmodium activity inside infected red blood cells, furthermore, levels of uric acid correlate with the development of intracellular malaria parasites. Hypoxanthine resulting from the breakdown of haemoglobin by Plasmodium species is very important in malaria pathogenesis, because plasmodia use it as a nutrient and after rupture of schizonts the remaining of it is converted to uric acid due to the action of Xanthine oxidase, and that gave a strong linkage between malaria pigment density and severity of malaria infection. Uric acid is the main cause of arthritis which is one of the common clinical features of malaria, it induces the inflammatory response and many cytokines involved, genes related to hyperuricemia involved discrepancy of clinical outcomes between malaria patients.
  • No Thumbnail Available
    Item
    Medicinal Plants Explain the Significant Role of Uric Acid for Malaria Parasite
    (جامعة الشيخ عبدالله البدري, 2021-12-13) Mosab Nouraldein Mohammed Hamad; , Sufian Khalid M. Noor; Awadalla H Kashif; , Mohammed Medani Eltayeb; Abdelgadir Elamin Eltom; , Praveen Kumar Kandakurti; , Elizabeth Popova; Shafie Abdulkadir Hassan; , Yassin Bakri Salih; , Tarig Mohammed Elfaki; d Mohammed Ahmed Ibrahim Ahmed
    Medicinal plants, recognized and employed in conventional medicine practices since prehistoric era. Plants produce thousands of chemical substances for functions counting defence against insects, fungi, bacterial and parasitic diseases. Malaria is most widespread parasitic infection , it caused by coccidian protozoa of the genus plasmodium , four species are mostly infect human, P. falciparum, P. vivax, P. malriae and P. ovale, Majority of malaria cases resulted from P. falciparum and P. vivax. Uric acid regarded as one of the damaging molecular patterns of malaria parasite infection, and in this review we discussed the potential role of medicinal plants used as antimalarial to diminish the level of uric acid in gout patients. These may suggest that most of the complication associated with malaria, may attributed to amplified level of uric acid . Experimental studies recommended.
  • No Thumbnail Available
    Item
    Pattern of ABO and Rhesus Blood Group Distribution among Students of Jamhuriya University of Science and Technology, Mogadishu, Benadir, Somalia
    (جامعة الشيخ عبدالله البدري, 2021) Shafie Abdulkadir Hassan; Mosab Nouraldein Mohammed Hamad
    ABSTRACT Background: Based on the presence or absence of antigen A and B on the surface of red blood cells ABO blood groups are divided into A, B, AB and O blood group. In addition to the presence of D antigen Rhesus blood group is divided into Rhesus positive and Rhesus negative. The purpose of this study is to determine the frequency and distribution of both ABO and Rhesus blood types among students of Jamhuriya University students of Science and Technology. Results: This descriptive and cross-sectional study was conducted between April 2021 and June 2021. A total of 350 students including 255 males and 95 females took part in the study. The distribution of ages was between 16 and 47 years. The blood group O was the most common blood group (59.7%), subsequently blood group A (28.9%), then blood group B (9.2%) and AB (2.3%). Most of the participants were Rhesus positive (95.8%) while 4.2% were Rhesus negative. Conclusions: Blood group O was the most common blood group in the study, then A, B, and AB respectively. 95.8% were Rhesus positive; only 4.2% were Rhesus negative.