Browsing by Author "Rahma Abdo Ahmed Osman"

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    Evaluation of Prothrombin Time Activated Partial Thrombo- plastin Time and Fibrinogen Level in Diabetic Pregnant Women in Shendi Town, Sudan
    (جامعة الشيخ عبدالله البدري, 2023-09-01) Mosab Nouraldein Mohammed Hamad; Alsayed Nouh M. Aldoush; Mohammed Osman Ali; Rahma Abdo Ahmed Osman; ,Tibyan Abd Almajed Altaher; Ghanem Mohammed Mahjaf; Ammar abdelmola5
    Abstract Background: Pregnancy is a unique physiological event that might have an impact on a woman›s coagulation and fibrinolytic system. Pregnant women and fetuses may be at risk for thrombotic and bleeding problems due to an abnormally hypercoagulable state during diabetic pregnancy. Thus, pregnant women must have regular coagulation tests to keep track of their coagulation and fibrinolytic systems. Objective: This research was carried out to analyze Prothrombin Time, Activated Partial Thromboplastin Time, and fibrinogen level in diabetic pregnant and normal pregnant women in Shendi town in Almak Nemer hospital during the period from June to November 2021. Materials and Methods: In tri-sodium citrate, 150 venous blood samples total were taken, 100 from diabetic pregnant women as cases and 50 from healthy pregnant women as controls. A questionnaire was employed to gather certain patient-related data. Coagulometer tests were performed on blood samples. Results: It was found that pregnant women with diabetes had a significant increase in PT and APTT but a minor increase in fibrinogen when compared to the control result. PT and PTT values were insignificant increase with age, number of pregnancies, and thestage of pregnancy. Conclusions: In diabetic pregnant women, alterations in the levels of coagulation markers were seen. And the coagulation parameter ranges were reported, which can serve as a point of reference for medical professionals to more precisely monitor the coagulation and fibrinolytic system in pregnant diabetic patients.
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    Vitamin A and Male Reproduction
    (جامعة الشيخ عبدالله البدري, 2023-07) Mosab Nouraldein Mohammed Hamad; Rahma Abdo Ahmed Osman; Tibyan Abd Almajed ALtaher; Ghanem Mohammed Mahjaf
    Abstract: Vitamin A is essential for various functions in the human body, including growth, epithelial differentiation, eyesight, immune system function, men's reproduction, and male infertility by enhancing sperm quality, bioenergetics, functioning, maintaining mitochondrial stability, and reducing oxidative damage. Males require dietary retinoid or vitamin A for spermatogenesis, as spermatogonial stem cells start the process through periodic RA after birth. Blood-testis barrier interactions and RA signals are crucial to the process of spermatogenesis. Spermatogenesis is a significant inducer of spermatogenesis in the mammalian testis. The undifferentiated spermatogonia are started by RA at the beginning of the 72-day spermatogenesis process in humans. The immune system, which is aided by vitamin A, mediates reactive oxygen species (ROS) activity and protects reproductive organs from oxidative stress. Beta-carotene (inactivated) and retinol (activated) are the two major forms of vitamin A that circulate in the body. Retinoic acid may contribute to male fertility through its impact on sperm quantity and shape. Vitamin A deficiency can stop spermatogenesis prematurely, but longterm chronic high vitamin A intake harms sperm viability, production, and morphology. Vitamin A measurement is crucial for understanding lipid peroxidation, which is a significant risk factor for human spermatozoa. Infertile patients may have higher levels of reactive oxygen species production, which could be a cause of idiopathic infertility. The body's defenses against oxidative damage rely heavily on lipid-soluble antioxidants like vitamin A, which includes beta-carotene. High levels of these vitamins have protective effects against disease by reducing lipid peroxidation. Techniques for measuring retinol include immunoassay technology, reverse phase open column chromatography, and monoclonal antibody-based immuno-enzymometric tests. High-performance liquid 3 chromatography (HPLC) is a quick and reliable method for estimating retinol levels simultaneously in serum and seminal fluid.