Browsing by Author "Mohammed Medani Eltayeb"

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    Frequency of Urinary Schistosomiasis Among School –Aged Children in Al-Lamab Area, Khartoum – Sudan
    (جامعة الشيخ عبدالله البدري, 2020-10-01) Mohanad E Elfadol; Mohammed Medani Eltayeb; Mosab Nouraldein Mohammed Hamad
    Abstract Background: Urinary schistosomiasis is a sickness initiated by parasitic flukes named Schistosoma haematobium, if left untreated, can eventually lead to anemia, malnutrition, renal failure, or bladder carcinoma. The illness occurs mostly among school-aged children and young adults in sub-Saharan Africa. Rationale: Bilharzia is one of the most parasitic diseases with grave complications that may lead to sterility, kidney failure and bladder cancer Objectives: To know the frequency of urinary schistosomiasis among school-aged children in the al-lamab area. Materials and Method: Descriptive, cross-sectional study, 314 urine specimens were collected from each participant and examined by filtration and sedimentation methods. Result: the prevalence among 314 individuals about 10.2 % (32) screening by filtration and sedimentation technique, the results showed (10.2%) were positive by filtration and (7.3%) positive by sedimentation. The positive cause within each age groups showed 7- 10 (2.9%),11-!4 (4.4%) and 15-18 ( 2.9%), The age groups 11-14 years its highest infection than other groups. The results showed that all infective children had hematuria and 78.1% proteinuria. Conclusion: the prevalence of rate is highest in the age group 11-14 years in comparison to other age groups. The filtration technique is more sensitive than the sedimentation technique
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    Impact of Uric Acid in Malaria Outcomes
    (جامعة الشيخ عبدالله البدري, 2021) Mosab Nouraldein Mohammed Hamad; Yassin Bakri Salih; Sufian Khalid M. Noor; Awadalla H Kashif; Mohammed Medani Eltayeb; Bader Saud Alotaibi; Elizabeth Popova; Rania Saad Abdulgader; Abdelgadir Elamin Eltom; Shafie Abdulkadir Hassan; Tarig Mohamed Elfaki1; Mohammed Ahmed Ibrahim Ahmed
    Up to the date variations of malaria pathogenesis between human populations signify important trouble facing scholars concerned with malaria pathology. Pathogen-associated molecular patterns may be one of the main keys to the well understanding of malaria mechanism and dissimilarity of clinical outcomes of the disease between people. Uric acid is regarded as a dangerous alarming metabolite, resulting from plasmodium activity inside infected red blood cells, furthermore, levels of uric acid correlate with the development of intracellular malaria parasites. Hypoxanthine resulting from the breakdown of haemoglobin by Plasmodium species is very important in malaria pathogenesis, because plasmodia use it as a nutrient and after rupture of schizonts the remaining of it is converted to uric acid due to the action of Xanthine oxidase, and that gave a strong linkage between malaria pigment density and severity of malaria infection. Uric acid is the main cause of arthritis which is one of the common clinical features of malaria, it induces the inflammatory response and many cytokines involved, genes related to hyperuricemia involved discrepancy of clinical outcomes between malaria patients.