Browsing by Author "Mohammed Abdelgader Elsheikh"

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    Cytological Changes in Buccal Mucosa among Glue Abusers in Shendi, Sudan
    (جامعة الشيخ عبدالله البدري, 2023) Mosab Nouraldein Mohammed Hamad; Mazin Babekir Musa Bashi; Ghanem Mohammed Mahjaf; Tibyan Abd Almajed Altahe; Abdelgader Awad Alami; Amna Sanhoury Eesa; Mohammed Abdelgader Elsheikh
    Abstract Background: Glue sniffing among young people on the streets has gone completely out of control. The majority of street kids start out sniffing glue before moving on to other, more extreme narcotics. The organizations tackling the drug problem claim that because it is inexpensive and widely accessible, the majority of young people on the streets smell it. Objective: The purpose of this study was to assess how sniffing glue affected the buccal mucosal cells. Materials and Methods: This cross-sectional descriptive study was carried out at Shendi town between March 2021 and March 2022. The study involved 150 participants under the age of 25, of whom 50 were glue abusers. The remaining 50 participants served as the (control1) group, and their parameters were similar to those of the abusers', with the exception that they did not abuse glue. The final 50 participants served as the (control 2) group, and they appeared to be in good health and did not use tobacco, Glue sniffing, or another type of addiction. Buccal samples were taken from each group, strained by pap stain, and microscopically examined. A standardized face-to-face questionnaire was utilized to gather data, and the (SPSS) version (11.5) application was used to analyze the results. Results: The study revealed a significant P-value of nuclear atypia among study populations, inflammation, and infection was 0.000, the significant relationship of nuclear atypia with the duration of glue snuffing and dose of glue with P-value 0.000,0.001 respectively. Conclusions: The usage of glue caused considerable morphological alterations in mucosal cells, such as nuclear atypia and pre-nuclear hallo, as well as inflammations and infections (bacterial and viral)
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    Immunohistochemical Expression of CDX2 as Early Biomarkers for Gastric Intestinal Metaplasia among Sudanese Patients with Chronic Gastritis
    (جامعة الشيخ عبدالله البدري, 2023-09-13) Zeinab Ali Mohamed; Ibrahim B Elemam; Mohammed Abdelgader Elsheikh; Tibyan Abd Almajed Altaher; Ghanem Mohammed Mahjaf; Mosab Nouraldein Mohammed Hamad
    Abstract: Background: Chronic gastric infection with Helicobacter pylori can cause intestinal metaplasia, a pathologic change that is frequently a precursor of gastric cancer; CDX2 has an essential role in the development and maintenance of intestinal differentiation in the gut and ectopic sites such as intestinal metaplasia of the stomach. Objective: This study aimed to investigate caudal-type home box (CDX2) Immuno expression as an early indicator for gastric intestinal metaplasia among Sudanese patients with chronic gastritis. Materials and methods: This is a descriptive retrospective cross-sectional study conducted at Atbara Medical Complex and El-MakNimr University Hospital at River Nile State in the period from 2019 to 2022. 140 archival paraffin tissue blocks were collected from patients diagnosed with chronic gastritis, immunohistochemistry was used to detect (CDX2 expression as an early indicator for gastric intestinal metaplasia. Results: From 140 samples, 80 were females (57.1 %) and 60 were males (42.9%), the patient's ages ranged from (12 to 97) with a mean age of (53.27) years, and age was categorized into three groups, less than 40 (27) (19.3%), 40- 60 (64) (45.7%), more than 60 (49) (35.0%). The prevalence of gastric intestinal metaplasia was (17.9%, while no statistically significant correlation of gastric intestinal metaplasia with gender and age as the P.value was (0.308 and 0.256) respectively. Conclusion: The development of gastric intestinal metaplasia as a premalignant condition of gastric carcinoma is important to detect this change at an early point to prevent and control gastric cancer.
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    Role of Combine Alcian Blue and Periodic Acid Schiff’s in Demonstration of Adenocarcinomas and Poorly Differentiated Cancers
    (جامعة الشيخ عبدالله البدري, 2023-09-25) Manahil Fthelrhman Hamadoba; Mohammed Abdelgader Elsheikh; ,Ahmed Mohammed Ahmed; Marium Faez Habib; ,Tibyan Abd Almajed Altaher; ,Ghanem Mohammed Mahjaf; Mosab Nouraldein Mohammed Hamad
    Abstract Background: Mucins are complex carbohydrates secreted by various types of epithelial cells and glandular tissue in many organs. Mucin's pathological expression has been implicated in cancer development and progression. Diagnosis of adenocarcinoma is based on morphological appearance under light microscopy. Detection of mucins may also help identify adenocarcinoma and poorly differentiated carcinomas.