Browsing by Author "Abdelgadir Elamin Eltom"
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Item Impact of Uric Acid in Malaria Outcomes(جامعة الشيخ عبدالله البدري, 2021) Mosab Nouraldein Mohammed Hamad; Yassin Bakri Salih; Sufian Khalid M. Noor; Awadalla H Kashif; Mohammed Medani Eltayeb; Bader Saud Alotaibi; Elizabeth Popova; Rania Saad Abdulgader; Abdelgadir Elamin Eltom; Shafie Abdulkadir Hassan; Tarig Mohamed Elfaki1; Mohammed Ahmed Ibrahim AhmedUp to the date variations of malaria pathogenesis between human populations signify important trouble facing scholars concerned with malaria pathology. Pathogen-associated molecular patterns may be one of the main keys to the well understanding of malaria mechanism and dissimilarity of clinical outcomes of the disease between people. Uric acid is regarded as a dangerous alarming metabolite, resulting from plasmodium activity inside infected red blood cells, furthermore, levels of uric acid correlate with the development of intracellular malaria parasites. Hypoxanthine resulting from the breakdown of haemoglobin by Plasmodium species is very important in malaria pathogenesis, because plasmodia use it as a nutrient and after rupture of schizonts the remaining of it is converted to uric acid due to the action of Xanthine oxidase, and that gave a strong linkage between malaria pigment density and severity of malaria infection. Uric acid is the main cause of arthritis which is one of the common clinical features of malaria, it induces the inflammatory response and many cytokines involved, genes related to hyperuricemia involved discrepancy of clinical outcomes between malaria patients.Item Medicinal Plants Explain the Significant Role of Uric Acid for Malaria Parasite(جامعة الشيخ عبدالله البدري, 2021-12-13) Mosab Nouraldein Mohammed Hamad; , Sufian Khalid M. Noor; Awadalla H Kashif; , Mohammed Medani Eltayeb; Abdelgadir Elamin Eltom; , Praveen Kumar Kandakurti; , Elizabeth Popova; Shafie Abdulkadir Hassan; , Yassin Bakri Salih; , Tarig Mohammed Elfaki; d Mohammed Ahmed Ibrahim AhmedMedicinal plants, recognized and employed in conventional medicine practices since prehistoric era. Plants produce thousands of chemical substances for functions counting defence against insects, fungi, bacterial and parasitic diseases. Malaria is most widespread parasitic infection , it caused by coccidian protozoa of the genus plasmodium , four species are mostly infect human, P. falciparum, P. vivax, P. malriae and P. ovale, Majority of malaria cases resulted from P. falciparum and P. vivax. Uric acid regarded as one of the damaging molecular patterns of malaria parasite infection, and in this review we discussed the potential role of medicinal plants used as antimalarial to diminish the level of uric acid in gout patients. These may suggest that most of the complication associated with malaria, may attributed to amplified level of uric acid . Experimental studies recommended.